The Mayo Clinic Rare and Undiagnosed Disease Hackathon

Inclusion Criteria: * Patients receiving or having received care at Mayo Clinic with rare or undiagnosed conditions; of any age (including pediatric); who can provide informed consent or have a legally authorized representative (LAR). * Patients who have undergone prior standard genetic testing that was non-diagnostic; and who are nominated by a Mayo Clinic clinician sponsor and selected by the Study Team. Exclusion Criteria: * Patients with a confirmed molecular or clinical diagnosis that fully explains their phenotype * Patients unable to provide consent and without a legally authorized representative (LAR) * Patients for whom sample collection cannot be coordinated * Patients enrolled in a clinical trial that precludes ancillary genomic research (evaluated on a case-by-case basis) * Prisoners will not be included in this study