This is a single-center, non-randomized, open-label, parallel-group study. It will test D-2570 in people with liver problems and in people with healthy livers, to see how the drug moves through the body and whether it is safe.
This is a single-center, non-randomized, open-label, parallel-controlled study designed to evaluate the pharmacokinetic profile and safety of D-2570 in participants with hepatic impairment and those with normal hepatic function. Participants with hepatic impairment will be enrolled first, followed by participants with normal hepatic function.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
24
D-2570 tablet, administered orally as a single dose
The First Affiliated Hospital of Bengbu Medical University
Bengbu, Anhui, China
RECRUITINGThe main PK parameters -Time to maximum measured plasma concentration -Tmax Population pharmacokinetic characteristics of D-2570
The main PK parameters -Time to maximum measured plasma concentration -Tmax
Time frame: Up to 192 hours after the last dose
Maximum observed plasma concentration-Cmax
Maximum observed plasma concentration-Cmax
Time frame: Up to 192 hours after the last dose
The main PK parameters Half-life -t1/2
The main PK parameters Half-life -t1/2
Time frame: Up to 192 hours after the last dose
The main PK parameters#Area under the plasma concentration versus time curve-AUC
The main PK parameters#Area under the plasma concentration versus time curve-AUC
Time frame: Up to 192 hours after the last dose
The main PK parameters-CL/F (apparent clearance)
The main PK parameters-CL/F (apparent clearance)
Time frame: Up to 192 hours after the last dose
The main PK parameters-Vz/F (apparent volume of distribution)
The main PK parameters-Vz/F (apparent volume of distribution)
Time frame: Up to 192 hours after the last dose
Incidence of adverse events
Incidence of adverse events
Time frame: Up to Day9
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