Vitamin E Supplementation Effect in Management of Calcium Oxalate Crystals

University of Lahore48 enrolled

Overview

Nephrolithiasis is a condition characterized by the formation of crystalline stones in the urinary system. The most common component of these stones is calcium oxalate. The current study was proposed to explore the effect of different concentration of vitamin E supplementation on Calcium oxalate crystal among nephrolithiatic patients.

A randomized controlled trial (pre-post treatment) was conducted on 48 participants who met the inclusion criteria. The participants were selected from the OPD of Hussain Memorial Hospital in Lahore. They were divided into three groups, with each group consisting of 16 participants. The control group (T0) did not receive any treatment, while the treatment groups received different doses of Vitamin E supplementation. The first treatment group (T1) received 200mg of Vitamin E supplementation, and the second treatment group (T2) received 400mg of Vitamin E supplementation, both for a duration of 8 weeks. Data was collected at baseline and after the 8th week of the study, including blood samples for renal function tests (RFT), ultrasounds, and 24-hour urine samples for calcium and oxalate analysis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Nephrolithiasis Calcium Oxalate Kidney Stones

Interventions

Control Group T0DRUG

The participants were on conventional medicines

Intervention Group T1DIETARY_SUPPLEMENT

T1 group participants were taking 200mg/day of Vitamin E supplementation once a day along with conventional medicines

Intervention Group T2DIETARY_SUPPLEMENT

T2 group participants were taking 400mg/day of Vitamin E supplementation once a day along with conventional medicines

Eligibility

Sex: ALLMin age: 20 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Both male and female. * Participants between the age of 20-50 years old. * Presence of calcium oxalate crystals in urine and kidneys * The size of the stones will range from 2 to 5 mm. Exclusion Criteria: * People having stones of Uric acid, struvite, Cystine. * People having any other medical condition (End stage renal disease, Chronic Kidney disease, Kidney failure, and dialysis) . * Subjects were excluded if they were taking any medications, which might affect vitamin E metabolism (such as Wrafrin, dalteparin sodium, enoxaparin sodium). * Pregnant and lactating females. * People having known allergies to Vitamin E supplementation (rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing). * Participants enrolled in other studies or taking other nutraceutical preparations.

Locations (1)

The University of Lahore

Lahore, Pakistan

Outcomes

Primary Outcomes

Urine Analysis

The laboratory reading of urine analysis involves the identification and microscopic examination of urine to assess the characteristics and concentration of calcium and oxalate crystals present.

Time frame: 8 weeks

Renal function test

This involved measuring the levels of BUN (blood urea nitrogen) and creatinine in the blood.

Time frame: 8 weeks

Data from ClinicalTrials.gov

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