MyocarditIRM-Génétique - Genetic Sub-study of the French Cohort of Acute Myocarditis Cases Diagnosed by MRI

N/AActive Not RecruitingNCT07717073

French Cardiology Society602 enrolled

Overview

The aim of this retrospective, non-interventional study is to assess the prevalence and describe the genetic variants found in a cohort of patients with acute myocarditis confirmed by MRI. This is a study linked to the MyocarditIRM cohort, designed to collect genetic test results obtained as part of routine clinical care.

Study Type

OBSERVATIONAL

Enrollment

602

Conditions

Acute Myocarditis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient enrolled in MyocarditIRM * Patient who has undergone genetic testing Exclusion Criteria: * Patient who has objected to the reuse of their data

Locations (1)

CHU de Poitiers

Poitiers, France, France

Outcomes

Primary Outcomes

Prevalence and characterization of genetic variants (genes involved and ACMG classification) in patients with MRI-confirmed acute myocarditis.

Time frame: From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)

Secondary Outcomes

All-cause mortality

All-cause mortality during follow-up

Time frame: From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)

Cardiovascular mortality

Cardiovascular mortality during follow-up

Time frame: From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)

Major adverse cardiovascular events

Occurrence of major adverse cardiovascular events, including heart failure requiring hospitalization, newly diagnosed dilated cardiomyopathy not present prior to the myocarditis episode, ventricular arrhythmias, high-degree atrioventricular block, implantation of an implantable cardioverter-defibrillator (ICD), pacemaker, wearable cardioverter-defibrillator (life vest), or implantable loop recorder, recurrent myocarditis, and heart transplantation.

Time frame: During index hospitalization and up to 10 years of follow-up (via SNDS linkage and medical records)

Cardiac MRI sequelae

Presence of myocardial sequelae on cardiac magnetic resonance imaging (MRI) during follow-up in patients who underwent follow-up imaging as part of routine clinical care

Time frame: During follow-up imaging performed as part of routine clinical care, up to 10 years after index myocarditis episode

Data from ClinicalTrials.gov

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