Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery

N/ANot Yet RecruitingNCT07718373

Xijing Hospital5,000 enrolled

Overview

Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial function. investigators emulated a target trial to evaluate whether early perioperative L-arginine was associated with a lower risk of AKI after cardiac surgery.

Study Type

OBSERVATIONAL

Enrollment

5,000

Conditions

Acute Kidney Injury

Interventions

L-arginineDRUG

Initiation of L-arginine within 3 postoperative days

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: ·adults admitted to the ICU after CPB-assisted cardiac surgery Exclusion Criteria: * congenital heart disease, * surgery requiring deep hypothermic circulatory arrest, * a preoperative baseline estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m², * AKI already present prior to ICU admission

Outcomes

Primary Outcomes

Acute kidney injury

defined by KDIGO criteria

Time frame: within 7 postoperative days

Secondary Outcomes

7-day mortality.

Time frame: 7 day

Central Contacts

Zefei Zhang

CONTACT

18811797795 zzfanita7@163.com

Data from ClinicalTrials.gov

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