The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
950
zenagamtide will be taken orally.
Placebo matched to zenagamtide will be taken orally.
Relative change in body weight
Measured as percentage (%) change in body weight.
Time frame: From baseline (week 0) to (week 76)
Change in waist circumference
Measured as centimetre (cm)
Time frame: From baseline (week 0) to (week 76)
Change in systolic blood pressure (SBP)
Measured as millimetre of mercury (mmHg).
Time frame: From baseline (week 0) to (week 76)
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Pinnacle Research Group LLC
Anniston, Alabama, United States
Univ of Alabama Birmingham
Birmingham, Alabama, United States
Chambliss Clinical Trials LLC
Montgomery, Alabama, United States
Providence Medical Foundation
Fullerton, California, United States
Torrance Clinical Research Institute, Inc.
Lomita, California, United States
Diablo Clinical Research, Inc.
Walnut Creek, California, United States
Univ of Colorado at Denver
Aurora, Colorado, United States
ERG Holding Company, LLC / Evolution Research Group, LLC
Delray Beach, Florida, United States
Northeast Research Institute
Fleming Island, Florida, United States
Miguel Rebollar PA
Hialeah, Florida, United States
...and 27 more locations