This study proposes a multimodal analgesia regimen comprising preoperative non-steroidal anti-inflammatory drugs (NSAIDs) for preemptive analgesia, intra-articular injection at the end of surgery, and postoperative adductor canal block. The objective is to observe the analgesic efficacy and duration of hydromorphone combined with ropivacaine in the adductor canal block on resting and movement-related pain in patients following total knee arthroplasty, as well as the time to recovery from motor blockade and the incidence of drug-related adverse events.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
90
Ultrasound-guided single-shot ACB with 0.5 mg hydromorphone
Ultrasound-guided single-shot adductor canal block (ACB) with 20 mL of 0.5% ropivacaine
China-Japan Friendship Hospital
Beijing, Beijing Municipality, China
Visual Analog Scale (VAS) Pain Score
The co-primary outcomes consisted of resting pain score and dynamic pain score during active 45° knee flexion measured by the Visual Analog Scale (VAS). The scale ranges from a minimum value of 0 points (no pain) to a maximum value of 10 points (the worst imaginable pain); higher scores indicate more severe pain. Assessments were conducted at baseline before surgery, and at 4 hours, 8 hours, 12 hours and 24 hours after surgery.
Time frame: Preoperatively and at 4, 8, 12, and 24 hours postoperatively
Quadriceps strength
Secondary outcomes were quadriceps strength (Lovett scale, 0-5) before surgery and at 4, 8, 12, and 24 hours after surgery.
Time frame: Preoperatively and at 4, 8, 12, and 24 hours postoperatively
Postoperative analgesia-related adverse reactions
Time frame: At 4, 8, 12, and 24 hours postoperatively
Postoperative opioid use
Time frame: At 4, 8, 12, and 24 hours postoperatively
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