Minimally Invasive Non Surgical Treatment Using Injectable Platelet Concentrate in Treatment of Deep Pockets.

Cairo University48 enrolled

Overview

The purpose of this study is to evaluate change in pocket depth following using minimally invasive non surgical combined with injectable platelet concentrate .

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Intrabony Periodontal Defects

Interventions

Injectable PRFBIOLOGICAL

I-PRF will be prepared from 10 mL of autologous venous blood and injected into the cleaned defect, followed by placement of a custom-made transparent vacuum-formed stent for 15 minutes to prolong local contact

MINSTPROCEDURE

Participants will receive minimally invasive non-surgical periodontal therapy (MINST) alone using P3 Woodpecker piezoelectric scaler for the selected periodontal intrabony defect

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with periodontitis stage III-IV. * Presence of at least one intrabony defect with radiographic component ≥ 3mm deep and PPD≥ 6mm (not affecting a tooth with 'hopeless' prognosis). * Patients willing to sign informed consent and to be in the study until the 6-months follow-up. * Full-mouth plaque score \<30% following step 1 periodontal therapy Exclusion Criteria: * Smoker/vaper (currently or in past 5 years). * Contributory medical history (e.g. cardiovascular disease, diabetes, psychiatric conditions).

Locations (1)

Cairo University

Cairo, Egypt

RECRUITING

Outcomes

Primary Outcomes

Change in pocket depth

Baseline measurements will be taken at the first visit. Probing depth will be measured at six sites per tooth (mesiobuccal, midbuccal, distobuccal, mesiolingual, midlingual, distolingual) using a UNC-15 periodontal probe

Time frame: 6 months

Secondary Outcomes

Pocket closure

Pocket depth of less than or equal 4 millimeters with no bleeding on probing at 6-month follow-up. PD will be measured from the gingival margin to the base of the pocket at six sites per tooth using a UNC-15 periodontal probe. PD reduction will be calculated by subtracting the 6-month PD from baseline PD

Time frame: 6 months from baseline

Clinical attachment gain

CAL will be measured from the cementoenamel junction (CEJ) to the base of the pocket at the same six sites using a UNC-15 periodontal probe. CAL gain will be calculated by subtracting follow-up CAL (6 months) from baseline CAL

Time frame: 6 months from baseline

Radiographic defect reduction:

Periapical radiographs of selected study sites will be taken at baseline and at 6 months using the parallel technique with Rinn holders. Each participating practice used the same setting and exposure time for radiographs taken at both visits to standardize positioning and minimize distortion of sequential radiographs

Time frame: 6 months

Patient reported outcomes

To evaluate patient perceptions about the performed procedure and post-therapy period. The extent of discomfort and/or pain experienced will be evaluated using a horizontal visual analog scale (VAS) measured from scale from 1 to 10 where 1 is the lowest \& 10 is the highest.

Time frame: 6 months

Central Contacts

Hania Haggag

CONTACT

+01210239417 hania.haggag@dentistry.cu.edu.eg

Data from ClinicalTrials.gov

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