This pilot study will test how Fermented Papaya Preparation (FPP) impacts overall TEWL of areas that commonly display diminished barrier function, such as the skin from face, arms, and hands. Areas of diminished barrier function are defined as those not visible to the eye but identified as areas of high transepidermal water loss (TEWL) as measured by a non-invasive pen-like device. A TEWL value of 20 or higher at a location would be considered high TEWL. Participants will attend 5 visits over 20 weeks, with 12-weeks of FPP treatment, and 8-weeks of follow-up.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
30
Immun'Age Fermented Papaya Preparation
McGowan Institute for Regenerative Medicine
Pittsburgh, Pennsylvania, United States
Transepidermal Water Loss (TEWL)
9 anatomical sites. Unit g/m²/h
Time frame: From enrollment to the end of FPP at 12 weeks.
Skin surface pH
9 anatomical sites.
Time frame: From enrollment to the end of FPP at 12 weeks.
Skin surface temperature
9 anatomical sites. Unit Celsius
Time frame: From enrollment to the end of FPP at 12 weeks.
Monocyte Inflammation Marker
CD16
Time frame: From enrollment to the end of FPP at 12 weeks.
Glucose Levels
Unit mg/dL
Time frame: From enrollment to the end of FPP at 12 weeks.
HbA1c Levels
Percentage
Time frame: From enrollment to the end of FPP at 12 weeks.
Complete Blood Count (CBC)
Absolute Counts
Time frame: From enrollment to the end of FPP at 12 weeks.
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