Study to Evaluate the Safety and Efficacy of Humacyte's Coronary Tissue Engineered Vessel (CTEV) in Patients With Coronary Artery Disease Requiring Coronary Artery Bypass Grafting (CABG)

Inclusion Criteria: 1. Age ≥18 years with the ability to provide written informed consent. 2. Planned first isolated CABG surgery for atherosclerotic coronary artery disease with a planned LIMA graft to the LAD and at least one other planned vessel bypass. 3. An RCA or LCx territory target vessel for the CTEV graft with the following characteristics: 1. Target vessel stenosis of ≥80% (including total occlusion) or a fraction flow reserve (FFR) of ≤0.8. 2. Good target vessel quality with a diameter of at least 2.5 mm. 3. Good target vessel run-off as determined by the Investigator. Exclusion Criteria: 1. Recent (within 7 days) acute myocardial infarction. 2. Hemodynamic instability or need for emergent CABG surgery. 3. Acute heart failure or abnormal left ventricular wall motion (e.g., ejection fraction \<55%). 4. Ascending aortic pathology, including aneurysm, dissection, or significant calcification. 5. Prior cardiac surgery. 6. Planned concomitant valve or aortic surgery. 7. Known bleeding disorder or thrombophilia. 1. Thrombocytopenia (platelet count \<100 x 109/L) 2. Clinically significant anemia (hemoglobin \<9.0 g/dL) 3. Elevated prothrombin time (INR \> 1.3) or partial thromboplastin time (\>35 seconds) not due to anticoagulation therapy. 8. Required post-operative anticoagulation therapy. 9. Known or suspected allergies or contraindications to aspirin or clopidogrel, heparin, or contrast agents that cannot be adequately pre-treated. 10. Chronic kidney disease with eGFR \< 45 ml/min/1.73 m2). 11. Previous exposure to the Humacyte ATEV (Symvess). 12. Use of any investigational drug or device within 60 days. 13. Women of childbearing potential defined as not sterile or not at least 1 year postmenopausal. 14. Any condition, including active substance abuse, that in the opinion of the investigator, prevents participants from following the protocol, including the planned CT angiographic follow-up through at least 12-14 months. 15. Active infection requiring ongoing antibiotic therapy or conditions that would increase the risk of infection or other complications evidenced by the following: 1. Compromised immune function from medication or underlying disease 2. Clinically significant low white blood cell count (leukopenia) 3. Uncontrolled diabetes mellitus (HbgA1c \>8.0%, serum glucose \>300 mg/dL) 4. Active malignancy. 16. Clinically significant hepatic cirrhosis or dysfunction evident by any of the following laboratory abnormalities: 1. AST or ALT ≥3x ULN 2. low serum albumin \< 2.0 g/dL 3. high bilirubin \> 2 mg/dL) 17. Participants who are considered not suitable for on-pump CABG procedure.