The goal of this clinical trial is to proposes a novel Oral Motor and Cognitive Dual-Task Training (OMCDT) program that combines both oral motor exercises and cognitive tasks to improve brain and oral function at the same time. It will also learn about the safety of drug ABC. The main questions it aims to answer is: Does the OMCDT training can improve the oral and cognitive functions? Participants will: Take the OMCDT training once a week for 32 weeks Visit the lab twice in the intervention period (16-week, 32-week) for checkups and tests
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
66
Oral Motor and Cognitive Dual-Task Training (OMCDT) program that combines both oral motor exercises and cognitive tasks to improve brain and oral function at the same time, where the training includes 4 types of combined oral and cognitive functions.
The intervention will include four components: tongue-lip coordination exercises, tongue muscle strengthening exercises, lip and cheek muscle strengthening exercises, and mastication exercises. Each component will be repeated for seven rounds, with a 10-second rest interval between rounds. The intervention will be delivered once per week.
The Hong Kong Polytechnic University
Kowloon, Hong Kong
Proportion of participant randomized divided by proportion of people eligible
Recruitment rate will be assessed by calculating the proportion of participant randomized divided by proportion of people eligible.
Time frame: Week 16; Week-32
Number of participants that withdraw divided by number of participants randomized
Attrition rate will be assessed by calculating the number of participants that withdraw divided by number of participants randomized
Time frame: 16-week; 32-week
Proportion of participants who complete the allocated intervention with a minimum of 80% attendance
Intervention completion rate will be assessed by calculating the proportion of participants who complete the allocated intervention with a minimum of 80% attendance.
Time frame: 16-week; 32-week
Maximum tongue pressure
The tongue pressure will be measured three times using a tongue pressure meter (JMS Co., Ltd., Hiroshima, Japan) and the maximum value will be recorded.
Time frame: Baseline, 16-week, 32-week
Oral motor coordination
Cantonese-specific ODK test will be assessed by counting the number of monosyllabic, disyllabic, and trisyllabic Cantonese syllables (e.g., /bo1/, /bui1 dip6/, /bei2 daan6 gou1/) that the subject can speak out correctly over 5-second interval.
Time frame: baseline; 16-week; 32-week
Masticatory ability
Masticatory ability will be evaluated using xylitol chewing check gum (Lotte, Tokyo, Japan). Participants will be instructed to chew the xylitol chewing check gum for 60 seconds. After chewing, place the gum on white paper and compare against a standardized color scale.
Time frame: baseline; 16-week; 32-week
Self-reported oral health
The self-reported oral health will be evaluated by General Oral Health Assessment Index (GOHAI). the Chinese version of GOHAI include 12 items There are five response categories for each question (l=always, 2=often,3=sometimes,4=seldom,and 5=never). The GOHAI score was computed by adding up the scores of the responses to the 12 questions and a higher score indicates a better reported oral health status.
Time frame: Baseline, 16-week, 32-week
Global cognitive status
The total score of Hong Kong Version of Montreal Cognitive Assessment (HK-MoCA)
Time frame: Baseline, 16-week, 32-week
Executive function
The time in second used by completing the Trail Making Test Part A (TMT-A) and Part B (TMT-B)
Time frame: baseline; 16-week; 32-week
Memory
The score of Fuld Object Memory Evaluation and Modified Verbal Fluency Test (F.O.M.E. \& M.V.F.T.).
Time frame: baseline; 16-week; 32-week
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.