The goal of this clinical trial is to determine whether buffering, warming, or addition of hyaluronidase or tranexamic acid to lignocaine during eyelid injection of local anaesthesia reduce injection pain and procedure-related pain and improve perioperative haemostasis.
The aim of the project is to test the hypothesis that the following modifications during subcutaneous eyelid injection of local anaesthesia, compared to 2% lignocaine with 1:200,000 adrenaline, reduce injection pain and procedure-related pain and improve perioperative haemostasis. 1. Buffering of 2% lignocaine with 1:200,000 adrenaline by adding sodium bicarbonate; 2. Warming of 2% lignocaine with 1:200,000 adrenaline to 37°C; 3. Addition of hyaluronidase to 2% lignocaine with 1:200,000 adrenaline; and 4. Addition of tranexamic acid to 2% lignocaine with 1:200,000 adrenaline.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
80
Lignocaine buffered with sodium bicarbonate
Lignocaine warmed to body temperature
Lignocaine with hyaluronidase added
Alice Ho Miu Ling Nethersole Hospital
Hong Kong, Hong Kong
CUHK Medical Centre
Hong Kong, Hong Kong
Prince of Wales Hospital
Hong Kong, Hong Kong
Pain of injection of local anaesthesia
Pain of injection of local anaesthesia, measured by a pain rating visual analogue scale of minimum 0 to maximum 10 (10 refers to worst pain)
Time frame: Within 1 minute after injection of local anaesthesia
Pain encountered during the surgery
Pain encountered during the surgery, measured by a pain rating visual analogue scale of minimum 0 to maximum 10 (10 refers to worst pain)
Time frame: Within 15 minutes after surgery
Pain encountered one week after surgery
Pain encountered one week after surgery, measured by a pain rating visual analogue scale of minimum 0 to maximum 10 (10 refers to worst pain)
Time frame: One week after surgery
Postoperative ecchymosis at one week after surgery
Postoperative ecchymosis at one week after surgery, rated based on clinical photos using a standardised rating score of minimum 0 to maximum 5 (5 refers to worst ecchymosis)
Time frame: One week after surgery
Postoperative swelling at one week after surgery
Postoperative swelling at one week after surgery, rated based on clinical photos using a standardised rating score of minimum 0 to maximum 5 (5 refers to worst swelling)
Time frame: One week after surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Lignocaine with tranexamic acid added
2% lignocaine with 1:200,000 adrenaline