Grounded in the 'disease-syndrome combination' paradigm, this study endeavors to address the pivotal scientific issues pertaining to the clinical precision of Traditional Chinese Medicine (TCM) in managing Diminished Ovarian Reserve (DOR) classified as the Kidney Essence Deficiency type, through the application of systems biology technologies, including metabolomics.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
136
The experimental group took Shoutai Pills, 20 pills each time, twice daily, taken with water, continuously for 3 months
The experimental group took placebo Pills, 20 pills each time, twice daily, taken with water, continuously for 3 months
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
Number of MII oocyte
On the day of oocyte retrieval, the number of mature oocytes was observed under a microscope. Mature oocytes are defined as oocytes containing the first polar body.
Time frame: After 3 months of medication, ovulation induction was performed, followed by oocyte retrieval upon completion of the induction cycle. The number of mature oocytes was recorded on the day of retrieval.
FSH
Follicle-Stimulating Hormone
Time frame: Basline, and after 3 months of treatment
AMH
Anti-Müllerian Hormone
Time frame: Basline, and after 3 months of treatment
number of oocytes retrieved
Direct visualization under microscopy
Time frame: After 3 months of medication, ovulation induction was performed, followed by oocyte retrieval upon completion of the induction cycle. The number of mature oocytes was recorded on the day of retrieval.
AFC
antral follicle count
Time frame: Basline, and after 3 months of treatment
blastocyst formation rate
Number of blastocysts / (number of cleavage-stage embryos - number of transferred embryos
Time frame: After 3 months of medication, ovulation induction and oocyte retrieval for fertilization are performed, recorded as Day 0. Blastocysts form on days 5/6 post-fertilization; thus, the blastocyst formation rate is assessed on Day 6
proportion of good-quality embryos
Number of top-quality embryos / number of cleavage-stage embryos
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Time frame: After 3 months of medication, ovulation induction and oocyte retrieval for fertilization are performed, recorded as Day 0. Cleavage embryos form on day3 post-fertilization; thus, the rate is assessed on Day 3