Comparison of Efficacy and Safety Profile Between Moisturizers Containing a Combination of 5% Hydro-Urea, Ceramide, With MultiVesicular Emulsion Technology and Petrolatum on Dry Skin in the Elderly

Change in SRRC

Specified symptom sum score. Measuring dry skin using four variables (scale, roughness, redness, and cracking) in score ranged from 1 to 4 for each variable. The highest the value marks the driest skin

Time frame: Baseline (Day 0), Day 7, Day 28, and Day 31 (3 days post-treatment cessation).

Change in Skin Capacitance

SCap measured in (AU)

Time frame: Baseline (Day 0), Day 7, Day 28, and Day 31 (3 days post-treatment cessation).

Change in TEWL

Transepidermal water loss reflects the amount of water lost through evaporation

Time frame: Baseline (Day 0), Day 7, Day 28, and Day 31 (3 days post-treatment cessation).

Change in 5-D Pruritus Scale

This multidimensional questionnaire is used to measure itch intensity. The 5-D scale evaluates five domains of itch: duration, degree, direction, disability, and distribution. The total scores range from 5 to 25.

Time frame: Baseline (Day 0), Day 7, Day 28, and Day 31 (3 days post-treatment cessation).

Change in Dermatology Life Quality Index

The Dermatology Life Quality Index (DLQI) questionnaire is used to measure the impact of xerosis cutis on the subject's quality of life. The questionnaire evaluates symptoms, daily activities, leisure, work, personal relationships, and treatments. The total scores range from 0 to 30

Time frame: Baseline (Day 0), Day 7, Day 28, and Day 31 (3 days post-treatment cessation).

Adverse Events

Assessment of safety and tolerability by evaluating the occurrence of subjective side effects (including itching, discomfort, and stinging) and objective side effects (including contact dermatitis and folliculitis) following the application of the moisturizers.

Time frame: Assessed throughout the 31-day observation period