RESTORE-BLADDER (REgistry on STrategies for Organ pREservation in Muscle-invasive BLADDER Cancer)

N/ANot Yet RecruitingNCT07744958

Heinrich-Heine University, Duesseldorf100 enrolled

Overview

Removal of the urinary bladder (radical cystectomy) is a major surgical procedure that can have a permanent impact on a patient's quality of life. Consequently, some patients, despite having received comprehensive counseling and completing systemic therapy, decide against subsequent surgery or alternative radiotherapy. Recent scientific studies suggest that, for selected patients, an attempt at bladder preservation may be a medically justifiable option. However, it remains unclear which patients are truly suitable candidates for bladder-preserving management and which are not. The aim of this registry is therefore to collect and analyze clinical data from this specific patient population.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Muscle Invasive Bladder Cancer (MIBC)

Interventions

None. Registry.OTHER

None. Registry.

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged \>= 18 years, capable of providing informed consent * Histologically confirmed muscle-invasive urothelial carcinoma of the urinary bladder * Received perioperative systemic therapy in accordance with current guidelines and subsequently decline cystectomy or radiotherapy Exclusion Criteria: * Age \< 18 years * Lack of capacity to provide informed consent * No histological confirmed muscle-invasive urothelial carcinoma * No prior preoperative systemic therapy

RESTORE-BLADDER (REgistry on STrategies for Organ pREservation in Muscle-invasive BLADDER Cancer)

Overview

Conditions

Interventions

Eligibility

Outcomes

Primary Outcomes

Central Contacts