This prospective, multicenter randomized controlled trial aimed to investigate whether linked color imaging (LCI) could reduce the miss rate of sessile serrated lesions (SSLs) during tandem colonoscopy compared with conventional white-light imaging (WLI).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
2,072
Patients in the WLI then LCI withdrawal group first underwent careful endoscopic inspection with white-light imaging (WLI). The endoscopic setting was then switched to linked color imaging (LCI) for the second withdrawal. All polyps detected during both inspection passes were resected, and the number of lesions missed on the first withdrawal was subsequently calculated.
Patients in the LCI then WLI withdrawal group first underwent careful endoscopic inspection with linked color imaging (LCI). The endoscopic setting was then switched to white-light imaging (WLI) for the second withdrawal. All polyps detected during both inspection passes were resected, and the number of lesions missed on the first withdrawal was subsequently calculated.
sessile serrated lesions miss rate(SSLMR)
The number of SSL detected in the second-pass examination/total number of SSL detected in both two pass.
Time frame: One day
adenoma miss rate (AMR)
The number of adenomas detected in the second-pass examination/total number of adenomas detected in the two pass.
Time frame: One day
advanced adenomas miss rate (AAMR)
the number of advanced adenomas detected in the second-pass examination/total number of advanced adenomas detected in the two pass.
Time frame: One day
polyps miss rate (PMR)
the number of polyps detected in the second-pass examination/total number of polyps detected in the two pass.
Time frame: One day
sessile serrated lesions detection rate (SSLDR)
the number of patients with at least one sessile serrated lesion detected by linked color imaging or white light imaging, divided by the total number of patients.
Time frame: One day
adenomas detection rate (ADR)
the number of patients with at least one adenoma detected by linked color imaging or white light imaging, divided by the total number of patients.
Time frame: One day
advanced adenomas detection rate (AADR)
the number of patients with at least one advanced adenoma detected by linked color imaging or white light imaging, divided by the total number of patients.
Time frame: One day
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polyps detection rate (PDR)
the number of patients with at least one polyp detected by linked color imaging or white light imaging, divided by the total number of patients.
Time frame: One day