The purpose of this study is to conduct a retrospective review of oncology patients with a diagnosis of any solid tumor and lymphoma to identify a cohort with radiographically reported tumor thrombus or tumor compression of vasculature. Clinical and radiographic data will be collected on this cohort to understand the incidence and management of tumor thrombus or vascular compression, as well as relevant clinical outcomes, including bleeding, thrombus extension or embolism, and mortality.
Identify and characterize (by clinical, demographic, and radiographic data) pediatric and AYA solid tumor oncology patients with radiographic evidence of tumor thrombus. Assess clinical outcomes (bleeding, thrombus resolution, thrombus extension or embolization, and mortality related to anticoagulation treatment vs non-treatment of identified tumor thrombus. Identify and characterize pediatric and AYA solid tumor patients with a tumor compressing a vascular structure without thrombosis, as identified by review of radiographic reports.
Study Type
OBSERVATIONAL
Enrollment
1,900
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States
Anticoagulation or vascular intervention
Documentation in medical record of patient being placed on prophylactic or therapeutic anticoagulation or requiring therapeutic intervention (such as thrombectomy graft, stent, thrombolysis, or venoplasty)
Time frame: Baseline through study completion, an average of 1 year
Clinical bleeding event
Major and clinically relevant non-major bleeding per ISTH definition
Time frame: Baseline through study completion, an average of 1 year
Thrombus extension
Documented episode of thrombus extension or embolism, or bland thrombus formation
Time frame: Baseline through study completion, an average of 1 year
Stage of oncologic disease at diagnosis
As indicated by local vs metastatic disease spread
Time frame: Baseline through study completion, an average of 1 year
New vs relapsed oncologic disease
Patient presenting with a new diagnosis vs relapsed disease when tumor thrombus identified
Time frame: Baseline through study completion, an average of 1 year
Disease status at last follow up
a. Patient alive with no evidence of disease, alive with disease, dead of disease, died of other causes, lost to follow up
Time frame: Baseline through study completion, an average of 1 year
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