Effect of Titanium-Prepared Platelet-Rich Fibrin and Low-Level Laser Therapy on Postoperative Morbidity After Mandibular Third Molar Surgery

NEW Cyprus Health and Social Sciences University60 enrolled

Overview

This randomized double-blind clinical trial aims to evaluate the effects of titanium-prepared platelet-rich fibrin (T-PRF), low-level laser therapy (LLLT), and their combination on postoperative outcomes following surgical extraction of impacted mandibular third molars. Sixty patients will be randomly allocated to one of four parallel groups: T-PRF, LLLT, T-PRF plus LLLT, or control. The primary outcomes include postoperative pain assessed using a visual analogue scale (VAS), analgesic consumption, postoperative swelling and trismus. The findings may help identify effective approaches for improving postoperative recovery after mandibular third molar surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Impacted Mandibular Third Molar Extraction

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 31 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adults requiring surgical extraction of a unilateral vertically impacted mandibular third molar. * Healthy individuals (ASA I or II). * Ability to provide written informed consent. * Willingness to attend all follow-up visits. Exclusion Criteria: * Systemic disease affecting wound healing. * Pregnancy or lactation. * Active infection or acute pericoronitis. * Long-term opioid use. * Smoking and alcohol use. * Known allergy to study medications. * Previous radiotherapy to the head and neck region * Inability to attend follow-up visits.

Outcomes

Primary Outcomes

Postoperative Pain

Postoperative pain assessed using a 100-mm Visual Analog Scale (VAS).

Time frame: Postoperative Days 1, 2, 3, and 7

Analgesic Consumption

Number of analgesic tablets consumed after surgery.

Time frame: Postoperative Days 1, 2, 3, and 7

Facial Swelling

Postoperative facial swelling will be evaluated using standardized linear facial measurements. Three distances will be measured with a flexible measuring tape: tragus to the corner of the mouth (Tragus-Commissure), tragus to the soft-tissue pogonion (Tragus-Pogonion), and lateral canthus of the eye to the mandibular angle (Lateral Canthus-Gonion). The sum of the three measurements (in centimeters) will be recorded for each participant. Higher values indicate greater postoperative facial swelling.

Time frame: Preoperative baseline and Postoperative Days 1, 2, 3, and 7

Maximum Interincisal Mouth Opening (Trismus)

Postoperative trismus will be evaluated by measuring the maximum interincisal mouth opening using a calibrated ruler. The distance (in millimeters) between the incisal edges of the maxillary and mandibular central incisors during maximum mouth opening will be recorded for each participant. Lower values indicate greater postoperative trismus.