Radiation Therapy Approaches for People With Prostate Cancer

Phase 2RecruitingNCT07751159

Memorial Sloan Kettering Cancer Center126 enrolled

Overview

The purpose of the study is to explore the best ways of giving radiation therapy to balance cancer control and treatment side effects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

126

Conditions

Prostate Cancer Patients Non-metastatic Prostate Cancer High Risk Prostate Cancer

Interventions

Standard of Care HDR BrachytherapyRADIATION

HDR Brachytherapy

SBRTRADIATION

SBRT alone

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Non-metastatic prostate cancer. * Classified as unfavorable intermediate-, high-, or very high-risk prostate cancer according to NCCN risk stratification guidelines. (Note: cT3a or T3b by MRI or PSMA PET allowed) * Considered by the treating radiation oncologist as a suitable candidate for both HDR brachytherapy boost and SBRT Exclusion Criteria: * None

Locations (7)

Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)

Basking Ridge, New Jersey, United States

RECRUITING

Memorial Sloan Kettering at Monmouth (Limited Protocol Activities)

Middletown, New Jersey, United States

RECRUITING

Outcomes

Primary Outcomes

Change in International Prostate Symptom Score / IPSS at 3 months

Change in International Prostate Symptom Score / IPSS to measure if SBRT alone results in less acute patient reported urinary symptoms measured by IPSS at 3 months than HDR brachytherapy boost combined with SBRT

Time frame: 3 months

Central Contacts

Daniel Gorovets, MD

CONTACT

212-639-3983 gorovetd@mskcc.org

Himanshu Nagar, MD

CONTACT

212-639-6478 nagarh1@mskcc.org

Data from ClinicalTrials.gov

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