Personalized Neoantigen-pulsed Autologous Dendritic Cell Injections for Malignant Solid Tumors

Inclusion Criteria: * Participants must meet all of the following criteria: 1. Male or female participants aged 18 to 75 years, inclusive. 2. Histologically or cytologically confirmed malignant solid tumor. 3. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1. 4. Adequate hematologic function, including: 5. Adequate hepatic function: 6. Adequate renal function: 7. Adequate coagulation function: 8. Adequate pancreatic function: 9. Availability of sufficient tumor tissue and peripheral blood samples for whole-exome sequencing (WES), RNA sequencing (RNA-seq), and neoantigen identification. 10. Adequate peripheral venous access for peripheral blood mononuclear cell (PBMC) collection by leukapheresis. 11. Left ventricular ejection fraction (LVEF) ≥50%. 12. Estimated life expectancy of at least 3 months. 13. Women of childbearing potential must have a negative pregnancy test within 7 days before the first administration of study treatment. 14. Male participants and women of childbearing potential must agree to use highly effective contraception during treatment and for 3 months after the final administration. 15. Ability to understand and voluntarily sign written informed consent. 16. Willingness and ability to comply with study procedures and scheduled follow-up assessments. Exclusion Criteria: * Participants meeting any of the following criteria will be excluded: 1. T-cell-derived malignant tumors. 2. Previous allogeneic hematopoietic stem cell transplantation or solid organ transplantation. 3. Active autoimmune disease requiring systemic treatment. 4. Active uncontrolled bacterial, viral, fungal, or opportunistic infection. 5. Known human immunodeficiency virus (HIV) infection. 6. Active hepatitis B or hepatitis C infection that is not adequately controlled. 7. Clinically significant cardiovascular disease, including uncontrolled hypertension, unstable angina, myocardial infarction within 6 months, severe arrhythmia, or congestive heart failure. 8. Severe pulmonary, hepatic, renal, neurologic, psychiatric, or other uncontrolled systemic diseases judged by the investigator to interfere with study participation. 9. Pregnant or breastfeeding women. 10. Receipt of systemic immunosuppressive therapy within 14 days before leukapheresis, except physiologic corticosteroid replacement. 11. Receipt of blood transfusion, erythropoietin, granulocyte colony-stimulating factor (G-CSF), or granulocyte-macrophage colony-stimulating factor (GM-CSF) within 14 days before PBMC collection. 12. Inability to undergo leukapheresis. 13. Any condition that, in the investigator's opinion, would place the participant at unacceptable risk or compromise study integrity.