DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use Pharmacotherapy

Inclusion Criteria: * age 18+; * report nicotine-containing e-cigarette use 5+ times per day, \>5 days per week, for \> 6 months; * smoking \>1 cigarette per day, \>5 days per week, for \>6 months; * interest in quitting cigarettes and e-cigarettes within the next month (\>6 on 10-point scale); * willing to try nicotine replacement therapy; * access to text/internet/email. Exclusion Criteria: * report use of other tobacco or nicotine products (i.e., pouches, smokeless tobacco, hookah) \>1 time per week in the past 3 months; * have medical contraindications for nicotine replacement therapy use (patch and lozenge; e.g., recent myocardial infarction, arrhythmias, angina, vascular disease, or medical conditions in which consumption of phenylalanine is contraindicated such as PKU); * report current use of smoking cessation medications (varenicline, bupropion, other nicotine replacement therapies); * endorse symptoms of Cannabis Use Disorder (using the CUDIT assessment); * unable to consent (e.g., cognitive deficit, non-English speaking); * live outside the US.