Adapted Cardiopulmonary Resuscitation Study

Johannes Kepler University of Linz216 enrolled

Overview

The goal of this controlled single centre RCT is to compare frequency rates concerning return of spontaneous circulation (ROSC) in prehospital cardiac arrest. Two different algorithms (control-and interventiongroup) of advanced cardiac life support will be used to treat patients. In patients over 18 years suffering from cardiac arrest. The main question aims to answer if the frequency of ROSC differs between the groups receiving either the new Advanced Life Support (ALS) algorithm, or standard treatment. Researchers will compare the new algorithm to the standard care algorithm to see if there is a difference . Participants will be randomized to treatment on scene. The controlgroup will receive ALS standard treatment as performed in local protocols. The intervention group will receive a modified treatment including: * thorax compression via mechanical device (LUCAS 3) * head up Cardiopulmonary Resuscitation (cpr) * use of an impendance threshold device (ITD) module * arterial line placement * continuous epinephrin infusion via infusion pump * double sequence defibrillation

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

216

Conditions

Cardiac Arrest (CA)

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age\> 18 years * time of resuscitation \<21 minutes when enrollement starts Exclusion Criteria: * obvious pregnancy * contraindications for the use of Lucas 3 * time of resuscitation \>21 minutes and etCO2 \<15 mmHg upon arrival of the emergency physician on scene * Exclusion from the emergency physician from study due to futility.

Outcomes

Primary Outcomes

ROSC

frequency of ROSC in the study cohort

Time frame: one minute

Secondary Outcomes

Time to ROSC

comparison between the groups if ROSC can be achieved faster in one group

Time frame: Periprocedural: from enrollement to ROSC or Termination of Resuscitation (TOR)

CO2

Measurement of CO2 differences between study arms

Time frame: Periprocedural: from enrollement to ROSC orTOR

descriptive data

analyzing vital parameters measured

Time frame: Periprocedural: during study intervention