This study will evaluate three Investigational Medicinal Products (IMPs) called REGN9933, REGN7508, and REGN9533. The study is focused on participants with End-Stage Kidney Disease (ESKD) treated with hemodialysis and standard anticoagulant treatment, such as heparin, to reduce the risk of blood clots as they can lead to serious health problems or be life-threatening. Because participants with ESKD who have hemodialysis have a higher risk of bleeding, the IMPs could be a meaningful new therapeutic option. The main aim of the study is to see what side effects may happen from taking REGN9933, REGN7508, or REGN9533. The study is looking at several other research questions, including: * How much IMP is in the blood at different times and * If the IMPs affect the ability of the blood to clot normally
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
36
Administered per the protocol
Administered per the protocol
Administered per the protocol
Administered per the protocol
Occurrence of Treatment-Emergent Adverse Events (TEAEs)
Time frame: Up to approximately 78 days
Severity of TEAEs
Time frame: Up to approximately 78 days
Concentrations of REGN9933
Time frame: Up to approximately 78 days
Concentrations of REGN7508
Time frame: Up to approximately 78 days
Concentrations of REGN9533
Time frame: Up to approximately 78 days
Change in activated Partial Thromboplastin Time (aPTT)
Time frame: From baseline up to approximately 78 days
Change in Prothrombin Time (PT)
Time frame: From baseline up to approximately 78 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.