Innovative 3D Preclinical Models for Mature B-cell Malignancies to Advance Personalized Immuno and Combination Therapies

N/ANot Yet RecruitingNCT07759661

IRCCS San Raffaele64 enrolled

Overview

Adult patients with chronic lymphocytic leukemia (CLL), splenic marginal-zone lymphoma (SMZL) and hairy cell leukemia (HCL) followed at participating clinical sites will be enrolled and undergo sampling of additional amount of blood during the blood draws performed as part of standard clinical care. The project aims to develop and validate innovative patient-derived 3D bioprinted models that faithfully reproduce the key microenvironments of lymphoid tissues, enabling a more physiologically relevant study of mature B-cell malignancies.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Lymphocytic Leukemia (CLL)Splenic Marginal Zone Lymphoma Hairy Cell Leukemia (HCL)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥18 years * Diagnosis of CLL, SMZL or HCL * Participant is willing and able to autonomously give informed consent for participation in the study. Exclusion Criteria: \- Participant is unable or unwilling to provide informed consent for participation in the study

Locations (1)

Outcomes

Primary Outcomes

To generate 3D culture models from patients with CLL, SMZL, HCL

≥50% 3D culture models generated from patients with CLL, SMZL and HCL, defined as cell viability \>80% per sample in standard condition

Time frame: 36 months

Central Contacts

Cristina Scielzo, PhD

CONTACT

+390226436487 scielzo.cristina@hsr.it

Lydia Scarfò, MD

CONTACT

+390226436119 scarfo.lydia@hsr.it