Efficacy and Safety Of Fractional Carbon Dioxide Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans

Phase 1Not Yet RecruitingNCT07760181

Al-Azhar University34 enrolled

Overview

evaluate and compare the clinical Efficacy \& Safety Of Fractional Carbon Dioxide (Co₂) Laser Plus Topical Metformin In Treatment Of Acanthosis Nigricans.

combining fractional CO₂ laser with topical metformin may provide a synergistic therapeutic effect. This study aims to evaluate and compare the efficacy and safety of fractional CO₂ laser combined with topical metformin versus fractional CO₂ laser using a split-neck design

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Acanthosis Nigricans

Interventions

Topical metforminDRUG

applied to one half of the neck only

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * \- male or female patients aged 18-50 years * clinically \& dermoscopy diagnosed acanthosis nigricans involving the neck * skin types iii-v * stable systemic condition for at least 3 months * willingness to comply with study protocol and follow-up Exclusion Criteria: * \- pregnancy or lactation * malignancy-associated acanthosis nigricans * active skin infection or inflammatory dermatosis at the treatment site * history of keloid or hypertrophic scar formation * photosensitivity disorders * use of topical or systemic treatment for acanthosis nigricans within the last 4 weeks * previous laser treatment to the neck within the last 6 months

Outcomes

Primary Outcomes

Assessment of severity using the acanthosis nigricans area and severity index (ANASI) score at baseline and after completion of treatment

Time frame: 5-7 days

Secondary Outcomes

Physician global assessment (PGA)

Time frame: 5-7 days

Data from ClinicalTrials.gov

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