This is a randomized, controlled, two-phase crossover study will be conducted in adults aged 18-60 years with prediabetes to compare the effects of a CSIR-developed high-protein, low-glycaemic index rice with conventional rice. Phase I will evaluate acute postprandial glucose, insulin, C-peptide, GLP-1, and hunger/satiety responses, while Phase II will assess 72-hour continuous glucose monitoring (CGM) outcomes, including mean glucose and glycaemic variability. Eligible participants will be randomly assigned to receive both rice types in a crossover manner, with each participant serving as their own control. Individuals with diabetes, major systemic illnesses, abnormal liver or renal function, pregnancy, or glucose-lowering medication use will be excluded.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
36
High-Protein, Low-Glycaemic Index Rice
National Diabetes, Obesity and Cholesterol Foundation (N-DOC)
New Delhi, National Capital Territory of Delhi, India
Study Phase 1: Meal Tolerance Test
incremental area under the curve(mg/dL)
Time frame: 1 day
meal tolerance study
• Postprandial insulin response (pmol/L)
Time frame: 1 day
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