Innate Immune Cell Phenotypes and Early Fibrotic Repair in Acute Myocardial Infarction

Shanghai 10th People's Hospital50 enrolled

Overview

To determine the relationship of the phenotypes of neutrophils and monocytes with early fibrotic repair after acute myocardial infarction.

This study will enroll 50 patients with ST-segment elevation myocardial infarction (STEMI). Peripheral blood will be collected from these patients for immune cell subset analysis, serum cytokine evaluation, and neutrophil sorting for transcriptome sequencing. At 1 week after admission, cardiac magnetic resonance (CMR) will be performed to evaluate the myocardial salvage index, area of late gadolinium enhancement (LGE), microvascular obstruction (MVO), extracellular volume (ECV), and left ventricular ejection fraction (LVEF).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Myocardial Infarction

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: \---- Age \> 18 and ≤ 80 years old \- Patients with acute STEMI within 12 hours of symptom onset who are planned to receive PPCI Exclusion Criteria: * Prior revascularization * Known allergy to gadopentetate dimeglumine contrast agent * Pregnancy or planned pregnancy within the next 6 months * Life expectancy \< 1 year * Metallic implants or claustrophobia that precluded MRI * Severe COPD or inability to hold breath for MRI * Severe hepatic or renal dysfunction (ALT \> 5×ULN or eGFR \< 15 mL/min/1.73 m²)

Locations (1)

Shanghai Tenth People's Hospital

Shanghai, China

RECRUITING

Outcomes

Primary Outcomes

Major cardiac adverse outcome

The composite endpoint included cardiac death, non-fatal myocardial infarction, and rehospitalization for angina.

Time frame: At 12 months after enrollment

Secondary Outcomes

Cardiac remodeling measured by CMR

CMR will be performed to evaluate the cardiac fibrosis defined as area of late gadolinium enhancement (LGE).

Time frame: At 1 week after admission

Central Contacts

Jianhui Zhuang, MD

CONTACT

86-13621742833 jh_zhuang@tongji.edu.cn

Data from ClinicalTrials.gov

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