This study evaluates whether a non-invasive brain stimulation technique called Temporal Interference (TI) can reduce epilepsy-related abnormal brain activity and influence sleep-related brain rhythms in adults with focal drug-resistant epilepsy undergoing stereo-EEG monitoring for clinical care. Up to 30 participants will complete stimulation sessions during wakefulness and, when possible, natural non-REM sleep. Brain activity will be recorded using scalp EEG and implanted sEEG electrodes before, during, and after TI stimulation. Some participants may also receive subthreshold direct stimulation through implanted electrodes for comparison. The study aims to determine whether TI can reduce epilepsy biomarkers, alter sleep-related brain activity, and compare favorably with conventional direct electrical stimulation while remaining within established safety limits.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
30
Non-invasive electrical stimulation delivered through scalp electrodes using paired sinusoidal currents with differential carrier frequencies to create a low-frequency envelope targeting deep brain structures including the epileptic focus or thalamus.
Subthreshold biphasic electrical stimulation delivered through implanted stereo-EEG contacts, remaining below thresholds for after-discharges and perceptual sensations.
Interictal epileptiform discharge rate
The interictal epileptiform discharge (IED) rate per minute is a classical biomarker of epilepsy. It is derived from sEEG macro- and microcontacts.
Time frame: 20-minute baseline, 20-minute stimulation, 20-minute post-stimulation
Single-unit firing rate
single unit firing rate is the number of action potentials ("spikes") that an isolated neuron emits per second. It is derived from sEEG microcontacts.
Time frame: 20-minute baseline, 20-minute stimulation, 20-minute post-stimulation
High-frequency oscillations
The high-frequency oscillation rate per minute (frequency \>80 Hz) is an alternative biomarker of epilepsy. it is derived from sEEG macro- and microcontacts.
Time frame: 20-minute baseline, 20-minute stimulation, 20-minute post-stimulation
local field potential spectral power
The power of local field potentials in defined frequency bands (theta: 4-8 Hz, beta: 13-30 Hz, gamma: 30-100 Hz) will be measured from macro- and microcontacts.
Time frame: 20-minute baseline, 20-minute stimulation, 20-minute post-stimulation
Sleep microstructure
Sleep microstructure is comprised of sleep spindles (sleep specific transients of 10-16 Hz exceeding 0.5 seconds) and slow oscillations (delta wave transients \< 0.5 Hz) measured in scalp EEG and sEEG macrocontacts. Rates are provided per minute
Time frame: 20-minute baseline, 20-minute stimulation, 20-minute post-stimulation
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