Muscle Function Following Anterior Cruciate Ligament Reconstruction: Impaired Power Output in Physically Active Individuals

Centre Hospitalier Metropole Savoie110 enrolled

Overview

The goal of this clinical trial is to to determine the extent of the association between objective changes in the muscle function of the knee extensors (strength and power) and the function reported by the patient following ACL reconstruction surgery. The main questions it aims to answer is: \- Pre- and post-operative (6 months) changes in maximum knee extensor strength following ACL reconstruction, correlated with the IKDC-SKF score.

Before surgery : * The patient will undergo a series of assessment tests, including: * An assessment of the force-velocity and power-velocity relationships for each leg during a cycling task * An assessment of unilateral force-velocity and power-velocity relationships during a knee extension task * An assessment of maximum strength and explosive strength in isometric (static) mode of the knee extensors. * A questionnaire-based assessment of IKDC-SKF scores. Evaluations will be repeated at 3 and 6 month after surgery ; Patients will be monitored for up to 24 months following their surgery

Study Type

INTERVENTIONAL

Allocation

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

110

Conditions

ACL Surgery

Interventions

* Assessment of force-velocity and power-velocity relationships in each leg during a cycling task * Assessment of unilateral force-velocity and power-velocity relationships during a knee extension task * Assessment of maximum force and explosive force in isometric (static) conditions of the knee extensors. * Measurement of scores using questionnaires (IKDC-SKF).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients requiring isolated or complex ACL reconstruction (combined with a meniscal injury) * Patients who are physically active (Tegner score ≥ 4) and wish to resume such activity. * Patients with no history of surgery on the ipsilateral knee (i.e., native knee). * Patients able to comply with the study procedures * Patients who have given their free and informed written consent, having been informed of the purpose of the study, its procedure and its risks. * Be affiliated to a social security scheme. Exclusion Criteria: * Patient with comprehension difficulties * Recurrent rupture of the ipsilateral ACL * Multi-ligament injuries (i.e., injury to the medial collateral ligament, lateral collateral ligament or posterior cruciate ligament)

Locations (1)

Médipôle de Savoie

Challes-les-Eaux, France

RECRUITING

Outcomes

Primary Outcomes

Correlation of maximum knee extension strength to IKDC-SKF scores

Relationship (r coefficient) between 0-6 month delta of maximum knee extension strength measurements and International Knee Documentation Commitee-SKF scores (100: no limitation)

Time frame: 6 month

Secondary Outcomes

Peri-operatory trajectory of maximal dynamic force

Trajectory of evolution of F0 (maximal dynamic force) between baseline, 3 and 6 months, compared between legs (linear mixed effect model).

Time frame: 0, 3 and 6 month

Peri-operatory trajectory of maximal contraction velocity

Trajectory of evolution of V0 (maximal contraction velocity) between baseline, 3 and 6 months, compared between legs (linear mixed effect model).

Time frame: 0, 3 and 6 month

Peri-operatory trajectory of rate of force development

Trajectory of evolution of rate of force development between baseline, 3 and 6 months, compared between legs (linear mixed effect model).

Time frame: 0, 3 and 6 month

Peri-operatory trajectory of maximal isometric force

Trajectory of evolution of maximal isometric force (Fmax) between baseline, 3 and 6 months, compared between legs (linear mixed effect model).

Time frame: 0, 3 and 6 month

Peri-operatory trajectory of maximal dynamic force during cycling

Trajectory of evolution of maximal dynamic force (F0) during cycling between baseline, 3 and 6 months (linear mixed effect model, one fixed factor).

Time frame: 0, 3 and 6 month

Peri-operatory trajectory of maximal contraction velocity during cycling

Trajectory of evolution of maximal contraction velocity (V0) during cycling between baseline, 3 and 6 months (linear mixed effect model, one fixed factor).

Time frame: 0, 3 and 6 month

Determinants of fonctional prognosis

Multivariate analysis including the IKDC-SKF score at 24 months as dependant variable and, as predictors : 1. the 0-3 month delta of V0, F0, RFD and Fmax during knee extension on the operated leg. 2. the severity of the lesion (presence of associated lesions) 3. the presence of a pre-operatory rehabilitation.

Time frame: 0, 3 and 24 month

Determinants of fonctional prognosis

Multivariate analysis including the recurrence of ACL lesion at 24 months (0/1) as dependant variable and, as predictors : 1. the 0-3 month delta of V0, F0, RFD and Fmax during knee extension on the operated leg. 2. the severity of the lesion (presence of associated lesions) 3. the presence of a pre-operatory rehabilitation.

Time frame: 0, 3 and 24 month

Determinants of fonctional prognosis

Multivariate analysis including resuming physical activity at the pre-injury level at 24 months (0/1) as dependant variable and, as predictors : 1. the 0-3 month delta of V0, F0, RFD and Fmax during knee extension on the operated leg. 2. the severity of the lesion (presence of associated lesions) 3. the presence of a pre-operatory rehabilitation.

Time frame: 0, 3 and 24 month

Central Contacts

leo blervaque

CONTACT

04.79.96.58.13 leo.blervaque@ch-metropole-savoie.fr

Data from ClinicalTrials.gov

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