Effect of Thymoquinone 0.2% Gel on Bone Density, Bone Width, and Socket Preservation After Tooth Extraction

Kafrelsheikh University30 enrolled

Overview

This study aims to evaluate the clinical and radiographic effects of 0.2% Thymoquinone gel on bone density, bone width, and socket preservation after tooth extraction.

Tooth extraction triggers a cascade of biological events which lead to significant remodeling of the alveolar ridge, frequently resulting in reductions in both bone width and height. The concept of alveolar ridge preservation (ARP) has developed to address the bone resorption that follows extraction. ARP aims to maintain ridge dimensions and reduce the need for further augmentation before implant placement. Among these, the small-molecule Thymoquinone (TQ), derived from Nigella sativa, has demonstrated significant osteogenic, anti-inflammatory, and antioxidant effects in preclinical studies.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Radiographic Evaluation Bone Density Bone Width Socket Preservation Tooth Extraction Thymoquinone

Interventions

Gel foamDRUG

Patients will receive gel foam only.

Thymoquinone gel + gel foamDRUG

Patients will receive 0.2% thymoquinone gel + gel foam.

Nano-formulated 0.2% thymoquinone gel + gel foamDRUG

Patients will receive nano-formulated 0.2% thymoquinone gel + gel foam.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age: 18-50 years. * Both sexes. * Patients requiring extraction of upper posterior teeth will be recruited. Exclusion Criteria: * Healthy subjects with intact sockets after extraction. * Normal mouth opening and good oral hygiene. * No systemic conditions affecting bone healing.

Locations (1)

Kafrelsheikh University

Kafr ash Shaykh, Kafrelsheikh, Egypt

RECRUITING

Outcomes

Primary Outcomes

Change in alveolar bone density after tooth extraction

Alveolar bone density will be assessed radiographically using cone-beam computed tomography (CBCT). The change in bone density from baseline to the specified postoperative assessment will be compared.

Time frame: 3 months after tooth extraction

Secondary Outcomes

Change in alveolar bone width after tooth extraction

Alveolar bone width will be assessed radiographically using cone-beam computed tomography (CBCT). The change in alveolar ridge width from baseline to the postoperative assessment will be measured.

Time frame: 3 months after tooth extraction

Change in alveolar ridge dimension after tooth extraction

Alveolar ridge dimensions will be assessed radiographically using cone-beam computed tomography (CBCT). Changes in the dimensions of the alveolar ridge following tooth extraction will be measured and compared.

Time frame: 3 months after tooth extraction

Central Contacts

Muataz A Karimeh, Bachelor

CONTACT

00201027988331 moataz.karema1998@gmail.com

Data from ClinicalTrials.gov

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