Exertional dyspnea has a significant impact on a child's daily life. Current guidelines recommend performing an exercise challenge test to confirm or rule out exercise-induced bronchoconstriction (EIB). But the test is not widely available. The objective of this research is to identify the clinical and respiratory functional factors predictive of a positive exercise challenge test in children.
Exertional dyspnea is a frequent reason for consultation in pediatric pulmonology. The perception of dyspnea varies from one child to another, with some children over- or under- perceiving its intensity. Dyspnea has a significant impact on a child's daily life and quality of life and, in pediatrics, always raises the suspicion of exercise-induced asthma. Current guidelines recommend performing an exercise challenge test to confirm or rule out exercise-induced bronchoconstriction (EIB) if it is suspected. However, this test is not widely available. The objective of this research is to identify the clinical and respiratory functional factors predictive of a positive exercise challenge test in children. The potential benefit of this study is to better identify individuals who would benefit from undergoing an exercise challenge test.
Study Type
OBSERVATIONAL
Enrollment
100
CHRU de Nancy
Nancy, France
Presence of wheezing at exercise
Presence of reported exercise-induced wheezing, as documented in the subject's electronic medical record (yes/no; binary variable).
Time frame: The test duration (3 hours)
Presence of reported dyspnea at exercise
Presence of reported exercise-induced dyspnea, as documented in the subject's electronic medical record (yes/no; binary variable).
Time frame: The test duration 3 hours
Presence of reported cough at exercise
Presence of reported exercise-induced cough, as documented in the subject's electronic medical record (yes/no; binary variable).
Time frame: The test duration 3 hours
Presence of reported chest tightness at exercise
Presence of reported exercise-induced chest tightness, as documented in the subject's electronic medical record (yes/no; binary variable).
Time frame: The test duration 3 hours
Functional parameters - FEV1 z-score at baseline
Spirometric parameters measured before exercise testing - FEV1 z-score (forced expiratory volume in 1 sec) from spirometry performed before exercise testing and documented in the electronic folder of the patient
Time frame: The test duration 3 hours
Reported atopy
Presence of asthma or atopy history, as documented in the subject's electronic medical record (yes/no; binary variable).
Time frame: The test duration 3 hours
Reported clinical history
Reported early respiratory history (≥ 3 wheezing episodes before the age of 3 years; at least one episode of pneumonia or atelectasis), from the clinical history recorded in the electronic folder of the patients (yes/no, binary variable)
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Time frame: The test duration 3 hours
Functional parameters - FEV1/FVC z-score at baseline
Spirometric parameters measured before exercise testing - FEV1/FVC z-score (FVC = forced vital capacity) from spirometry performed before exercise testing and documented in the electronic folder of the patient
Time frame: The test duration 3 hours