This is a single-center, open-label, fixed-sequence, self-controlled Phase I clinical study with a planned enrollment of approximately 18 healthy participants.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
18
Evaluation of Cmax
o evaluate the Cmax of HS-10504 and M6-2 of HS-10504 administered alone and in combination with Rifampin
Time frame: 192 hours after administration of HS-10504
Evaluation of AUC0-t
o evaluate the AUC0-t of HS-10504 and M6-2 of HS-10504 administered alone and in combination with Rifampin
Time frame: 192 hours after administration of HS-10504
Evaluation of AUC0-∞
o evaluate the AUC0-∞ of HS-10504 and M6-2 of HS-10504 administered alone and in combination with Rifampin
Time frame: 192 hours after administration of HS-10504
Evaluation of Tmax
To evaluate the Tmax of HS-10504 and M6-2 of HS-10504 administered alone and in combination with Rifampin
Time frame: 192 hours after administration of HS-10504
Evaluation of t1/2z
To evaluate the t1/2z of HS-10504 and M6-2 of HS-10504 administered alone and in combination with Rifampin
Time frame: 192 hours after administration of HS-10504
Evaluation of λz
To evaluate the λz of HS-10504 and M6-2 of HS-10504 administered alone and in combination with Rifampin
Time frame: 192 hours after administration of HS-10504
Adverse events
To evaluate the Occurrence of adverse events
Time frame: Up to end of the study, approximately 3 months
complete blood count
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To evaluate the complete blood count (CBC) of HS-10504 administered alone and in combination with Rifampin.
Time frame: Up to end of the study, approximately 3 months.
urinalysis
To evaluate the urinalysis of HS-10504 administered alone and in combination with Rifampin.
Time frame: Up to end of the study, approximately 3 months.
coagulation tests
To evaluate the coagulation tests of HS-10504 administered alone and in combination with Rifampin.
Time frame: Up to end of the study, approximately 3 months.
blood pressure
To evaluate the blood pressure of HS-10504 administered alone and in combination with Rifampin
Time frame: Up to end of the study, approximately 3 months.
Pulse
To evaluate the Pulse of HS-10504 administered alone and in combination with Rifampin
Time frame: Up to end of the study, approximately 3 months.
body temperature
To evaluate the body temperature of HS-10504 administered alone and in combination with Rifampin
Time frame: Up to end of the study, approximately 3 months.