The purpose of this study is to evaluate the efficacy and safety of elecoglipron compared with placebo adjunct to diet and exercise for weight management, in adult participants living with obesity or overweight with or without T2DM.
This is a Phase III, randomized, double-blind, placebo-controlled, multicenter study evaluating the efficacy and safety of oral elecoglipron in adults with obesity or overweight, with or without type 2 diabetes mellitus. Participants will be randomized to receive elecoglipron or placebo in accordance with the study protocol. Efficacy and safety will be assessed throughout the study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
351
Elecoglipron film coated tablet once daily
Placebo matching elecoglipron film-coated tablet once daily
Percent change from baseline to Week 52 in body weight
Percent change from baseline to Week 52 in body weight.
Time frame: Week 52
Participants achieving at least 5% body weight loss at Week 52
Achieved at least 5% body weight loss from baseline at Week 52.
Time frame: Week 52
Participants achieving at least 10% body weight loss at Week 52
Achieved at least 10% body weight loss from baseline at Week 52.
Time frame: Week 52
Change in waist circumference from baseline to Week 52
Absolute change from baseline to Week 52 in waist circumference(cm).
Time frame: Week 52
AstraZeneca Clinical Study Information Center
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Research Site
Baotou, China
NOT_YET_RECRUITINGResearch Site
Beijing, China
NOT_YET_RECRUITINGResearch Site
Beijing, China
NOT_YET_RECRUITINGResearch Site
Beijing, China
NOT_YET_RECRUITINGResearch Site
Changde, China
NOT_YET_RECRUITINGResearch Site
Changsha, China
NOT_YET_RECRUITINGResearch Site
Changzhou, China
NOT_YET_RECRUITINGResearch Site
Chengdu, China
RECRUITINGResearch Site
Hefei, China
NOT_YET_RECRUITINGResearch Site
Huangshi, China
NOT_YET_RECRUITING...and 39 more locations