Topical Chlorhexidine and Metronidazole Gels for Gingival Inflammation

H.P. Government Dental College and Hospital Shimla120 enrolled

Overview

This randomized controlled clinical trial was undertaken to evaluate and compare the effectiveness of chlorhexidine gluconate gel (1%) alone and a combination gel containing chlorhexidine gluconate (0.5%) with metronidazole (1.5%) as adjuncts to scaling and root planing in the management of gingival inflammation over a period of 12 weeks. 120 participants were assigned to three groups: scaling and root planing with placebo gel, scaling and root planing with 1% chlorhexidine gluconate gel, and scaling and root planing with a combination of 0.5% chlorhexidine gluconate and 1.5% metronidazole gel. Clinical periodontal parameters were assessed to compare the effectiveness of the interventions in reducing plaque accumulation and gingival inflammation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

120

Conditions

Plaque Induced Gingivitis

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients aged between 18- 50 years. 2. Patients with at least \>20 teeth. 3. Patients with gingivitis and stage-1 grade A periodontitis. 4. Patients with clinical criteria of gingival index ≥ 1 (Loe and Silness). 5. Systematically healthy patient with no co-morbidities. 6. History of no active periodontal treatment in the last 6 months. Exclusion Criteria: 1. History of smoking or use of smokeless tobacco. 2. Pregnant or lactating females. 3. Subjects with removal or fixed dental prosthesis and undergoing orthodontic treatment. 4. Use of antibiotics in the last 30 days. 5. Subjects with hematological disorders, immunocompromised and any other systemic illnesses. 6. History of chronic alcoholism. 7. Allergic to Metronidazole or Chlorhexidine. 8. Patients on medications that have effects on gingival enlargements.

Outcomes

Primary Outcomes

Change in plaque index (PI)

"Plaque accumulation was assessed using the Silness and Löe Plaque Index. Scores range from 0 to 3, with higher scores indicating greater plaque accumulation and therefore a worse outcome. Change was assessed from baseline to 12 weeks."

Time frame: Baseline and 12 Weeks

Change in gingival index (GI)

"Gingival inflammation was assessed using the Löe and Silness Gingival Index. Scores range from 0 to 3, with higher scores indicating greater gingival inflammation and therefore a worse outcome. Change was assessed from baseline to 12 weeks."

Time frame: Baseline and 12 weeks

Change in Periodontal probing depth (PPD)

Periodontal probing depth was measured in millimeters using a periodontal probe to evaluate changes in periodontal pocket depth following the assigned intervention.