Safety and Efficacy of Cryoablation for Thyroid Tumors

Inclusion Criteria: 【Group 1: Papillary Thyroid Carcinoma (PTC) patients】 1. Pre-operative ultrasound evaluation shows the maximum tumor diameter \<1 cm; 2. Papillary thyroid carcinoma (PTC) confirmed by ultrasound-guided fine-needle aspiration (FNA) biopsy; 3. Solitary PTC confirmed by pre-operative ultrasound; 4. Imaging examinations demonstrate no extrathyroidal invasion, cervical lymph node metastasis or distant metastasis. 【Group 2: Benign thyroid nodule patients】 1. Benign nodule confirmed by puncture biopsy; 2. Preoperative ultrasound confirms solid nodule with maximum diameter greater than 2 cm; 3. Patients refuse surgical treatment or cannot tolerate surgery, voluntarily receive thyroid ablation therapy and sign the informed consent form. Exclusion Criteria: 【Group 1: Papillary Thyroid Carcinoma (PTC) patients】 * (1) Biopsy confirms high-risk subtype papillary thyroid carcinoma; (2) History of thyroid surgery or radiotherapy; (3) Complicated with malignant tumors in other sites; (4) Severe coagulation dysfunction, or patients taking oral anticoagulants who have not reached the required drug-withdrawal period; (5) Incomplete follow-up data. 【Group 2: Benign thyroid nodule patients】 1. Patients with uncorrected psychiatric disorders or consciousness disturbance who cannot cooperate with treatment; 2. Patients with neck extension disorders of various causes who cannot cooperate with treatment; 3. Severe coagulation dysfunction, or patients taking oral anticoagulants who have not completed the required drug withdrawal period; 4. Severe cardiopulmonary insufficiency and inability to lie supine for the procedure; 5. Unrecovered recurrent laryngeal nerve injury contralateral to the lesion.