The purpose of this study is to learn whether a yoga therapy program can improve quality of life and reduce symptoms in people undergoing stem cell transplantation compared with an enhanced standard care physical activity program.
Primary Objective: • Examine the efficacy of YT relative to SC on HSCT-specific QOL. Outcomes will be collected at baseline pre-transplant (pre-YT) and then day 0, 14, 30, 60, and 100 as well as 1-year post-transplant. Secondary Objectives and Endpoints: * Examine group differences in other patient-reported outcomes including general QOL and fatigue. * Explore group differences in psychosocial and functional outcomes and as possible mediators including stress, mental health (depression and anxiety), sleep disturbances, growth, self-efficacy, mindfulness, and objective functional measures as well as moderators of YT including demographic factors (sex, age, etc.), baseline psychosocial factors, and medical variables (e.g., autologous versus allogeneic transplant). * Explore YT's implementation through qualitative interviews.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
300
Yoga Therapy (YT) is an evidence-based mind-body practice recommended for cancer to relieve nausea, fatigue, pain, sleep disruption, psychosocial distress, musculoskeletal symptoms, and cognitive dysfunction, all common symptoms experienced during HSCT.
UT MD Anderson Cancer Center
Houston, Texas, United States
Safety and Adverse Events (AEs)
Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0
Time frame: Through study completion; an average of 1 year
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