The overall goal of this study is to develop Brillouin microscope as a novel tool for measuring biomechanical and hydration properties of human tissues in vivo.
Our long-term goal is to establish a direct, accurate, and clinically viable method for measuring corneal hydration, enabling earlier detection, more precise diagnosis, and improved management of corneal diseases and postoperative complications. The objective of this study is to develop and validate Brillouin based hydration mapping as a diagnostic tool to quantify water content in the cornea across healthy individuals and patients with diverse ocular conditions. Our central hypothesis is that spatially resolved Brillouin frequency shifts can reveal disease-specific hydration profiles that are not detectable through conventional thickness-based methods. This hypothesis is based on recent evidence from our group demonstrating that Brillouin microscopy is sensitive to hydration. The rationale for this research is that Brillouin-based hydration maps will offer an unprecedented, morphology-independent metric of corneal fluid balance, which could improve clinical decision-making in a range of pathologies.
Study Type
OBSERVATIONAL
Enrollment
90
Massachusetts General Brigham
Boston, Massachusetts, United States
RECRUITINGNumber of subjects to successfully complete Brillouin measurement without serious unanticipated adverse events related to application of the device.
Number and percentage of enrolled subjects who complete the single Brillouin imaging session without experiencing a serious unanticipated adverse event related to the investigational Brillouin Ocular Scanner, as determined by study staff monitoring during and immediately following the imaging procedure.
Time frame: Through completion of the single study visit, approximately 1-2 hours
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