The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics (PK) of RO7568282 compared with placebo in participants with early-stage Parkinson's disease (PD) on stable symptomatic monotherapy with levodopa.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
474
Time to a Confirmed Motor Progression Event From the Randomization Date, as Measured by the MDS-UPDRS Part III Score
Time frame: Up to at least Week 104
Change in Motor Signs From Baseline at Week 104, as Measured by the MDS-UPDRS Part III Score
Time frame: Baseline and Week 104
Time to Worsening of Participants' Motor Function, as Reported by the Participant in the Presence of a Confirmed Motor Progression Event
Time frame: Up to at least Week 104
Incidence of Adverse Events (AEs)
Time frame: Up to at least Week 104
Change From Baseline in Columbia-suicide Severity Rating Scale (C-SSRS)
Time frame: Up to at least Week 104
Plasma Concentrations of RO7568282
Time frame: Up to at least Week 104
Reference Study ID Number: BP46441 https://forpatients.roche.com/ No email attachments.
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