Hemodynamic Responses to Laryngoscopy and Tracheal Intubation

N/ANot Yet RecruitingNCT07783256

Assiut University70 enrolled

Overview

Laryngoscopy and tracheal intubation lead to tachycardia and hypertension due to increase in the plasma catecholamines subsequent to sympathetic stimulation.

Various prophylactic interventions have been tried to blunt the hemodynamic stress response to laryngoscopy and tracheal intubation. The ketamine-dexmedetomidine combination (ketodex) and ketamine-propofol combination (ketofol) may be of benefit in maintaining hemodynamic stability and reducing potential side effects of each drug.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Hemodynamic Response to Laryngoscopy and Tracheal Intubation

Interventions

ketodexDRUG

Patients will receive a single IV bolus dose of both ketamine and dexmedetomidine

ketofolDRUG

Patients will receive a single IV bolus dose of both ketamine and propofol

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients scheduled for elective middle ear surgery under general anesthesia, ASA status I-II, aged from 18 to 60 years old of either sex. Exclusion Criteria: * Full stomach or emergency surgery * Any known contraindications or allergy to ketamine, dexmedetomidine, or propofol * Pregnancy or breastfeeding women * Body mass index (BMI) \> 35 Kg/m2 * History of hepatic, renal, or cardiac disease * Patients in whom the duration of laryngoscopy will last more than 25 seconds * Chronic opioid use, or history of neuropsychiatric disorders * Patient refusal

Outcomes

Primary Outcomes

Heart rate accompanying laryngoscopy and tracheal intubation with cuff inflation

Assessed in beats per minute

Time frame: The fifth minute after laryngoscopy and tracheal intubation with cuff inflation

Central Contacts

Seham M Moeen, M.D.

CONTACT

01006386324 seham.moeen@aun.edu.eg

Mohammed F Aly

CONTACT

01002610390 rescu2016@aun.edu.eg

Data from ClinicalTrials.gov

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