Serum CTGF in Chronic Plantar Fasciitis

N/ANot Yet RecruitingNCT07785453

Kanuni Sultan Suleyman Training and Research Hospital60 enrolled

Overview

This observational study aims to evaluate serum Connective Tissue Growth Factor (CTGF/CCN2) levels in patients with chronic plantar fasciitis compared with asymptomatic controls. The study will also assess the associations between serum CTGF levels and clinical and ultrasonographic characteristics of chronic plantar fasciitis.

This is a single-center observational study including patients with chronic plantar fasciitis and asymptomatic controls. Serum CTGF/CCN2 levels will be evaluated, and their associations with clinical and ultrasonographic characteristics will be assessed.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Plantar Fasciitis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-65 years. * Written informed consent. * For the patient group: chronic plantar heel pain for at least 3 months, pain during the first steps in the morning or after prolonged rest, tenderness over the medial calcaneal tubercle, and clinical and ultrasonographic findings consistent with chronic plantar fasciitis. * For the control group: asymptomatic individuals without a previous diagnosis or clinical and ultrasonographic findings of plantar fasciitis. Exclusion Criteria: * Tarsal tunnel syndrome, calcaneal stress fracture, plantar fascia rupture, Achilles tendinopathy, heel fat pad syndrome, plantar fibromatosis, or other foot conditions causing plantar heel pain. * Diabetes mellitus. * Inflammatory rheumatic diseases or gout. * Chronic kidney or liver disease. * Malignancy. * Active infection or autoimmune disease * Pregnancy. * Previous foot or ankle surgery. * Corticosteroid injection, platelet-rich plasma (PRP), prolotherapy, extracorporeal shock wave therapy (ESWT), or other interventional treatment to the affected heel within the previous 3 months. * Serious systemic conditions that may affect serum CTGF/CCN2 levels.

Outcomes

Primary Outcomes

Serum CTGF/CCN2 Level

Serum Connective Tissue Growth Factor (CTGF/CCN2) levels will be measured in patients with chronic plantar fasciitis and asymptomatic controls.

Time frame: At baseline

Secondary Outcomes

Pain Severity

Pain severity will be assessed using a Visual Analog Scale (VAS), and its association with serum CTGF/CCN2 levels will be evaluated.

Time frame: At baseline

Foot Function Index

Functional status will be assessed using the Foot Function Index (FFI), and its association with serum CTGF/CCN2 levels will be evaluated.

Time frame: At baseline

Plantar Fascia Thickness

Plantar fascia thickness will be measured by musculoskeletal ultrasonography, and its association with serum CTGF/CCN2 levels will be evaluated.

Time frame: At baseline

Data from ClinicalTrials.gov

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