Optimizing Lymphatic Pumping for Influenza Vaccine Responses in Vulnerable Populations

N/ANot Yet RecruitingNCT07786467

Lake Erie College of Osteopathic Medicine50 enrolled

Overview

The investigators are studying if a specific osteopathic manipulative treatment protocol can improve the immune response (antibody titers) to seasonal influenza vaccination in vulnerable populations, including patients with advanced age and/or adiposity.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

No Disease or Condition is Being Directly Studied The Focus of the Study in Healthy Volunteers

Interventions

Osteopathic ManipulationOTHER

In this intervention, participants will receive 5 minutes of thoracic inlet myofascial release 2 days prior to influenza vaccination, the day of influenza vaccination and 4 days post-influenza vaccination.

Osteopathic manipulationOTHER

In this intervention, participants will receive osteopathic manipulation 2 days prior to influenza vaccination, the day of influenza vaccination, and 4 days post-influenza vaccination. The OMT will include thoracic inlet myofascial release, pectoral traction, rib raising, doming of the diaphragm, pelvic diaphragm release, popliteal fossa release, plantar myofascial release, passive Miller thoracic pump, liver pump, and spleen pump.

ShamOTHER

In this intervention, participants will receive no osteopathic treatments

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Willing to receive OMT * Willing to receive influenza vaccine * Older than 18 years of age Exclusion Criteria: * Younger than 18 years of age * Pregnancy or lactation * Unwilling to receive the influenza vaccine * Unwilling to receive OMT * Open wounds * Bone fractures * Moderate to severe osteoporosis * Severe COPD * Current/active infections * Mononucleosis infection within past 6 months * Liver cirrhosis * Cancer or metastatic disease * History of DVT, PE, or blood clotting disorder * Individuals taking blood thinning medications, except aspirin * Having a pacemaker or other thoracic medical devices

Locations (1)

Plaza 38 Medical Offices

Erie, Pennsylvania, United States

Outcomes

Primary Outcomes

Hemagglutinin inhibition assay

Hemagglutinin inhibition assay assess the antibody titers in patient's blood.

Time frame: baseline and 4 weeks post vaccination

Central Contacts

David Duriancik, Ph.D.

CONTACT

814-860-5139 dduriancik@lecom.edu

Irv Freeman, J.D., Ph.D.

CONTACT

724-552-2870 ifreeman1@lecom.edu

Data from ClinicalTrials.gov

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