Impact of Intraoperative Perfusion Variability on Postoperative Troponin Elevation in Geriatric Patients Undergoing Major Oncologic Surgery

N/ANot Yet RecruitingNCT07786753

Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital70 enrolled

Overview

This prospective observational study aims to evaluate the association between intraoperative perfusion variability and postoperative troponin elevation in geriatric patients undergoing major oncologic surgery. Intraoperative hemodynamic and perfusion-related parameters will be recorded, and postoperative troponin levels will be assessed to investigate whether intraoperative perfusion changes are associated with myocardial injury. Troponin measurements will be obtained preoperatively and at 24 hours after surgery

Study Type

OBSERVATIONAL

Enrollment

Conditions

Postoperative Troponin Elevation Intraoperative Perfusion

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 65 years or older * Undergoing major abdominal oncologic surgery * Availability of preoperative and 24-hour postoperative troponin measurements * Complete intraoperative and postoperative patient monitoring records * Provision of written informed consent Exclusion Criteria: * Age younger than 65 years * Absence of preoperative or 24-hour postoperative troponin measurements * Incomplete intraoperative or postoperative patient monitoring records * Undergoing emergency surgery * Advanced heart failure * ASA Physical Status IV * Pulmonary artery pressure \>40 mmHg

Locations (1)

Outcomes

Primary Outcomes

Change in Serum Troponin Concentration From Preoperative Baseline to 24 Hours After Surgery

Postoperative troponin elevation will be assessed by comparing serum troponin levels measured preoperatively and 24 hours after surgery. Its association with intraoperative perfusion variability will be evaluated.

Time frame: Preoperatively and 24 hours after surgery

Secondary Outcomes

Association Between Intraoperative Perfusion Index and Postoperative Troponin Elevation

Perfusion Index (PI) will be continuously monitored intraoperatively and recorded at 15-minute intervals. The association between intraoperative PI values and postoperative troponin elevation at 24 hours after surgery will be evaluated.

Time frame: Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively

Association Between Intraoperative Pleth Variability Index and Postoperative Troponin Elevation

Pleth Variability Index (PVI) will be continuously monitored intraoperatively and recorded at 15-minute intervals. The association between intraoperative PVI values and postoperative troponin elevation at 24 hours after surgery will be evaluated.

Time frame: Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively.

Association Between Intraoperative Cerebral Oxygen Saturation and Postoperative Troponin Elevation

Cerebral oxygen saturation measured by near-infrared spectroscopy (NIRS) will be continuously monitored intraoperatively and recorded at 15-minute intervals. The association between intraoperative cerebral oxygen saturation values and postoperative troponin elevation at 24 hours after surgery will be evaluated.

Time frame: Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively.