The goal of this clinical trial is to learn if a daily ubiquinol supplement can reduce fatigue and help maintain muscle strength in adults aged 30-65 who are taking a GLP-1 weight loss medication (Wegovy® or Mounjaro®). Ubiquinol is a form of Coenzyme Q10 (CoQ10), a substance the body makes naturally that plays a key role in energy production. The main questions it aims to answer are: Does ubiquinol lower fatigue levels compared to a placebo (a look-alike capsule that contains no ubiquinol)? Does ubiquinol help maintain muscle strength during weight loss treatment? Researchers will compare ubiquinol to a placebo to see if ubiquinol helps with fatigue and muscle strength in people using GLP-1 medications. Participants will: Take one ubiquinol (100 mg) or placebo capsule every day for 9 months Have a nurse visit their home 4 times (at months 0, 3, 6, and 9) to take a small blood sample, measure their body, and supervise a simple sit-to-stand exercise test. Attend a short monthly video call (about 20-30 minutes) with a study dietitian. Complete questionnaires and 4 days of diet logging every 3 months using a smartphone app. Log all exercise sessions in the smartphone app throughout the study. This is a fully remote study - participants do not need to visit a clinic. About 90 people will take part.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
90
The active intervention is a commercially available ubiquinol dietary supplement. The dose is one 100mg capsule per day taken.
The placebo is manufactured by the same manufacturer that produces the active product. The placebo is visually similar to the active product and will be packaged in the same bottles as the active intervention to maintain the blind. The dose is one 100mg capsule per day taken with the first meal of the day. The product is stored at room temperature.
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RECRUITINGSelf-reported fatigue
Measured via Chalder Fatigue Scale score
Time frame: 9 months
Quality of life questionnaire
Measured via WHOQoL-BREF
Time frame: 9 months
Skeletal muscle function
Measured via 5 x sit-to-stand test
Time frame: 9 months
Body Mass
Body Mass measured in kg
Time frame: 9 months
Blood pyruvate levels
At each sampling timepoint, approximately 8 mL of blood will be drawn from the antecubital vein. Blood sampling, processing and analysis is managed by a third party company, following their own standard operating procedures.
Time frame: 9 months
Blood Lactate levels
At each sampling timepoint, approximately 8 mL of blood will be drawn from the antecubital vein. Blood sampling, processing and analysis is managed by a third party company, following their own standard operating procedures.
Time frame: 9 months
Blood Coenzyme Q10 levels
At each sampling timepoint, approximately 8 mL of blood will be drawn from the antecubital vein. Blood sampling, processing and analysis is managed by a third party company, following their own standard operating procedures.
Time frame: 9 months
Blood Creatine Kinase levels
At each sampling timepoint, approximately 8 mL of blood will be drawn from the antecubital vein. Blood sampling, processing and analysis is managed by a third party company, following their own standard operating procedures.
Time frame: 9 months
Blood Vitamin D levels
At each sampling timepoint, approximately 8 mL of blood will be drawn from the antecubital vein. Blood sampling, processing and analysis is managed by a third party company, following their own standard operating procedures.
Time frame: 9 months
Blood Ferritin levels
At each sampling timepoint, approximately 8 mL of blood will be drawn from the antecubital vein. Blood sampling, processing and analysis is managed by a third party company, following their own standard operating procedures.
Time frame: 9 months
Blood Magnesium levels
At each sampling timepoint, approximately 8 mL of blood will be drawn from the antecubital vein. Blood sampling, processing and analysis is managed by a third party company, following their own standard operating procedures.
Time frame: 9 months
Blood Total Cholesterol levels
At each sampling timepoint, approximately 8 mL of blood will be drawn from the antecubital vein. Blood sampling, processing and analysis is managed by a third party company, following their own standard operating procedures.
Time frame: 9 months
Blood LDL levels
At each sampling timepoint, approximately 8 mL of blood will be drawn from the antecubital vein. Blood sampling, processing and analysis is managed by a third party company, following their own standard operating procedures.
Time frame: 9 months
Blood HDL levels
At each sampling timepoint, approximately 8 mL of blood will be drawn from the antecubital vein. Blood sampling, processing and analysis is managed by a third party company, following their own standard operating procedures.
Time frame: 9 months
Blood Triglycerides levels
At each sampling timepoint, approximately 8 mL of blood will be drawn from the antecubital vein. Blood sampling, processing and analysis is managed by a third party company, following their own standard operating procedures.
Time frame: 9 months
Blood Vitamin B12 levels
At each sampling timepoint, approximately 8 mL of blood will be drawn from the antecubital vein. Blood sampling, processing and analysis is managed by a third party company, following their own standard operating procedures.
Time frame: 9 months
Blood HBA1C levels
At each sampling timepoint, approximately 8 mL of blood will be drawn from the antecubital vein. Blood sampling, processing and analysis is managed by a third party company, following their own standard operating procedures.
Time frame: 9 months
Height
Measured in metres
Time frame: 9 months
Body Mass Index
Measured in kg/m²
Time frame: 9 months
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