A study to assess the Capacitation - in-vitro maturation (CAPA-IVM) system as an option for patients with a good ovarian reserve to achieve pregnancy.
CAPA-IVM is being evaluated for its feasibility as an In vitro maturation (IVM) system in US fertility clinics. IVM is a laboratory process for maturing immature oocytes (eggs) outside of the body after egg retrieval. Egg retrievals are performed without prior ovarian stimulation.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
40
CAPA-IVM is a two-step IVM process to mature oocytes in the laboratory after egg retrieval.
Aspire Fertility Houston
Houston, Texas, United States
Metaphase II rate
The metaphase II (MII) rate is defined as the number of oocytes that reach MII stage of development divided by the number of cumulus-oocyte-complexes (COCs) placed into CAPA-IVM culture.
Time frame: Assessed approximately 40 hours after egg retrieval
Number of MII oocytes
The number of oocytes that reach the metaphase II (MII) stage of development after CAPA-IVM culture
Time frame: Assessed approximately 40 hours post egg retrieval
Fertilization rate
The fertilization rate is defined as the number of embryos that have 2 pro-nuclei post fertilization by intracytoplasmic sperm injection (ICSI)
Time frame: Assessed 16-18 hours post fertilization
Number of blastocysts
The number of embryos that make it to the blastocyst stage of development post fertilization
Time frame: Assessed 5-7 days post fertilization
Number of blastocysts vitrified
The number of embryos that are cryopreserved by vitrification post fertilization
Time frame: Assessed 5-7 days post fertilization
Number of blastocysts submitted for PGT-A
The number of embryos that are biopsied and samples sent for PGT-A testing
Time frame: Assessed 5-7 days post fertilization
Number of euploid blastocysts
Number of embryos that had a euploid result from PGT-A testing
Time frame: Assessed 2-4 weeks post embryo biopsy
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Positive beta-hCG rate
The number of patients with a serum QHCG level greater than 5 after embryo transfer divided by the total number of embryo transfers
Time frame: Assessed 9-11 days post embryo transfer
Ongoing pregnancy rate
The number of patients who have an ongoing intrauterine pregnancy at the last study visit
Time frame: Assessed approximately 10 weeks post embryo transfer
Live birth rate
Number of patients who had a live birth after embryo transfer
Time frame: Assessed approximately 40 weeks post embryo transfer