This prospective, multicenter observational study will evaluate glucose profiles using continuous glucose monitoring (CGM) in 100 adults with diabetes receiving peritoneal dialysis (PD) or planning to start PD within 3 months. The study will examine associations between CGM metrics and PD regimen, glucose-lowering treatment, conventional glycemic markers, dialysis-related measures, and clinical outcomes including glycemic emergencies, hospitalizations, cardiovascular events, and mortality over 12 months.
Study Type
OBSERVATIONAL
Enrollment
100
Sibionics GS3 CGM
Department of Medicine and Therapeutics, The Chinese University of Hong Kong
Hong Kong, Hong Kong
Continuous glucose monitoring-derived metrics
CGM derived time in ranges
Time frame: During period of 14 day CGM wear
HbA1c
HbA1c by venous blood
Time frame: Baseline to end of study period month 12
24-hour dialysate and ultrafiltration volume
24-hour dialysate and ultrafiltration volume,
Time frame: Baseline through to month 12
Residual renal function
Defined by 24-hour urine volume
Time frame: From baseline through 12 months
Hospitalization for hyperglycemic or hypoglycemic emergencies
Incidence of hospitalization due to hyperglycemic or hypoglycemic emergencies during follow-up
Time frame: From baseline through 12 months
Hospitalizations, cardiovascular events, and all-cause mortality
Incidence of all-cause hospitalization, major cardiovascular events, and all-cause mortality during follow-up
Time frame: From baseline through 12 months
Dietary intake during CGM wear
Dietary intake assessed using a 3-day food diary
Time frame: During the 14-day CGM wear period
Health-related quality of life
EuroQol 5-Dimension 5-Level questionnaire (EQ-5D-5L) overall score
Time frame: Baseline
Quality of life specific to kidney disease
Kidney Disease Quality of Life-36 questionnaire (KDQOL-36) total score
Time frame: Baseline
CGM user satisfaction
Total score from 10-item CGM user satisfaction questionnaire
Time frame: Baseline and month 3
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