The purpose of this study is to learn how well orforglipron works and how safe it is in Chinese adults with obesity or overweight and related health problems. Participation in this study will last about 53 weeks (about 1 year).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
192
Administered orally.
Administered orally.
Sichuan Provincial People's Hospital
Chengdu, China
Zhujiang Hospital
Guangzhou, China
The first Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, China
Mean Percent Change From Baseline in Body Weight
Time frame: Baseline, Week 48
Mean Change from Baseline in Waist Circumference
Time frame: Baseline, Week 48
Mean Change from Baseline in Body Mass Index (BMI)
Time frame: Baseline, Week 48
Mean Change from Baseline in Hemoglobin A1c (HbA1c)
Time frame: Baseline, Week 48
Mean Change from Baseline in Fasting Glucose
Time frame: Baseline, Week 48
Mean Percent Change from Baseline in Fasting Insulin
Time frame: Baseline, Week 48
Mean Change from Baseline in Systolic Blood Pressure (SBP)
Time frame: Baseline, Week 48
Mean Change from Baseline in Diastolic Blood Pressure (DBP)
Time frame: Baseline, Week 48
Mean Percent Change from Baseline in Fasting non-HDL Cholesterol
Time frame: Baseline, Week 48
Mean Percent Change from Baseline in Fasting Triglycerides
Time frame: Baseline, Week 48
Mean Change from Baseline in Short Form Version 2 (SF-36v2) Acute Form Domain Scores
Time frame: Baseline, Week 48
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
Physicians interested in becoming principal investigators please contact
CONTACT
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Zhejiang Provincial People's Hospital
Hangzhou, China
The Fourth Affiliated Hospital of Harbin Medical University
Harbin, China
The Second People's Hospital of Hefei
Hefei, China
Jinan Central Hospital
Jinan, China
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang Shi, China
Jiangxi Provincial People's Hospital
Nanchang, China
Nanjing First Hospital
Nanjing, China
...and 3 more locations