Comparison of KIRA Hydrating Treatment and Jet Peel for Facial Skin Hydration

Faculty of Pharmacy Novi Sad23 enrolled

Overview

This study compared the effects and tolerability of two non-invasive facial treatment systems on skin hydration: a hydroabrasion-jet system (KIRA) and a conventional high-pressure jet system (JET PEEL). Twenty-three women aged 30-65 years underwent three treatment sessions in an intraindividual split-face design, with KIRA applied to the left side of the face and JET PEEL to the right side. Skin hydration was assessed by corneometry at baseline, 48 hours after the first treatment, before the second treatment, and before the third treatment; the measurement before the third treatment was the primary endpoint. Additional exploratory assessments included multispectral skin imaging, participant-reported treatment experience and preference, and a 21-day follow-up. The study evaluated differences in hydration outcomes between a protocol combining vacuum-assisted hydroabrasion with 5-bar jet infusion and a conventional high-pressure jet treatment at 6.89 bar.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Facial Skin Hydration Skin Rejuvenation

Interventions

Vacuum-Assisted HydroabrasionDEVICE

Vacuum-assisted hydroabrasion was used for epidermal preparation. The intervention was applied to the left facial side during three treatment sessions.

High-Pressure Jet InfusionDEVICE

Jet-based treatment and infusion at 6.89 bar was applied to the right facial side during three treatment sessions.

Jet Infusion at 5 BarDEVICE

Jet infusion at 5 bar was applied to the left facial side following vacuum-assisted hydroabrasion during each of the three treatment sessions.

Eligibility

Sex: FEMALEMin age: 30 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Female participants aged 30-65 years * Fitzpatrick skin types II-III * Presence of signs of facial skin aging, including one or more of the following: hyperkeratosis, hyperpigmentation, facial or age-related wrinkles, and enlarged pores * Generally healthy and without contraindications to the study procedures * Willing and able to provide informed consent and participate in the study procedures Exclusion Criteria: * Pregnancy or breastfeeding * Serious vascular disorders * Pacemaker or metal implants in the treatment area * Malignant skin disease * Autoimmune or endocrine disease, diabetes, or acquired immunodeficiency syndrome * Psoriasis, herpes, or other active skin disease * Infection in the treatment area * Tendency toward keloid scarring or allergic reactions * Long-term corticosteroid therapy or other medication considered incompatible with the procedures * Hyaluronic acid filler or botulinum toxin injections in the treatment area * Tattoo or permanent makeup in the treatment area * Invasive aesthetic procedures within the previous 5 months * Failure to meet the inclusion criteria

Outcomes

Primary Outcomes

Change in Facial Skin Hydration From Baseline to Before the Third Treatment Session

Facial skin hydration was measured separately on the KIRA-treated and JET PEEL-treated facial sides using corneometry. The primary outcome was the change in corneometer-measured skin hydration, expressed in arbitrary units (a.u.), from baseline (T0) to the measurement before the third treatment session (T3). The within-participant difference in change between the two facial sides was used for the primary comparison.

Time frame: Baseline (T0) to before the third treatment session (T3; approximately 14 days)