This study compares the effectiveness of two adjunct therapies- photobiomodulation (low-level laser therapy) (PBM) and localized platelet-rich plasma (PRP) injections in accelerating orthodontic tooth movement. Participants receiving clear aligner therapy will be randomly assigned to one of three groups: clear aligners with PBM, clear aligners with PRP, or clear aligners alone (control group). The goal is to evaluate the efficiency, tooth movement tracking and safety.
This randomized controlled clinical trial evaluates the acceleration orthodontic tooth movement using two adjunct biological stimulation modalities in patients under going clear aligners therapy participant are allocated into three groups: 1. Clear aligner + photobiomodulation (PBM) : receives low-level laser therapy at specific intervals to stimulate cellular turnover and bone remodeling 2. Clear aligner +platelet-rich plasma (PRP) :receives localized autologous injections in the target tooth movement area to facilitate biological response 3. Clear aligners alone: (control group )receiving standard clear aligners treatment without additional interventions. Outcomes will be evaluated periodically using digital intra-oral scanning to measure tracking, accuracy, rate of orthodontic tooth movement, and soft tissue - periodontal health throughout the active treatment period.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
42
local submucosal injection of Autologous Platelet Rich Plasma (PRP) into the targeted alveolar site to evaluate its clinical effectiveness in accelerating orthodontic tooth movement
extra-oral application of photobiomodulation (PBM) Therapy to the targeted alveolar site to evaluate its clinical effectiveness in accelerating orthodontic tooth movement
Clear aligner worn for 22-hour on the first day of each aligner stage, followed by a daily wear duration of 12-hour per day for the remaining period in combination with acceleration modalities
Faculty of Dentistry Sanaa university
Sanaa, Sanaa Governorate, Yemen
Rate of clinical tooth movement via intraoral digital scans
Quantitative measurement of cumulative linear displacement and dental crown movement (in millimeters) calculated after every 2- aligners sequence (every 4 weeks) measurement will be obtained using digital intra-oral scan superimposed across all three study groups.
Time frame: Every 4 weeks from baseline up to 6 months
Root apex displacement
Assessment of root apex displacement in millimeters using CBCT superimposition
Time frame: Baseline and 6 months
Patient-Reported Pain Level
Pain intensity is evaluated using the Visual Analog Scale from 0 to 10, where 0 indicates no pain and 10 represents the worst possible pain. Higher scores indicate worse pain.
Time frame: At baseline, 24 hours, 48 hours, day 3, day 7 and day at aligner change up to 6 months.
Root resorption
Assessment of root resorption in millimeters using CBCT superimposition
Time frame: Baseline and 6 months
Peri-tooth alveolar bone density
Assessment of peri-tooth alveolar bone density changes in Hounsfield Unit (HU) using CBCT superimposition.
Time frame: Baseline and 6 months
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Clear aligners worn for the standard conventional duration of 22-hour per day without additional acceleration interventions