Bedside Ultrasound Measurement of Optic Nerve Sheath Diameter for Detecting Raised Intracranial Pressure

N/ANot Yet RecruitingNCT07799714

Assiut University85 enrolled

Overview

Raised intracranial pressure (ICP) is a serious medical emergency that requires prompt recognition to prevent brain damage. While invasive pressure monitoring and brain CT scans are commonly used, bedside transorbital ultrasonography to measure optic nerve sheath diameter (ONSD) offers a rapid, non-invasive alternative. The purpose of this study is to evaluate the diagnostic accuracy of bedside ultrasound measurement of ONSD in detecting raised ICP in adult patients, using brain CT scan findings as the reference standard. Adult patients clinically suspected of having elevated intracranial pressure and referred for a brain CT scan will undergo a non-invasive bedside ocular ultrasound examination. The optic nerve sheath diameter will be measured in both eyes and compared with independent CT brain interpretations to assess sensitivity, specificity, and the optimal diagnostic cut-off value.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Intracranial Hypertension Increased Intracranial Pressure Brain Edema Traumatic Brain Injury

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults aged ≥ 18 years * Clinical suspicion of acutely raised intracranial pressure (e.g., altered level of consciousness, papilledema, progressive headache, vomiting, or focal neurological deficits) * Referred to undergo a brain CT scan * Hemodynamically stable at the time of ultrasound examination Exclusion Criteria: * Pre-existing orbital or ocular trauma * Known history of optic nerve disease (e.g., optic neuritis or glaucoma) * Previous ocular or intraorbital surgery * Severe ocular pathology preventing safe transorbital ultrasonographic assessment * Refusal to participate or lack of informed consent from the patient or legal guardian

Outcomes

Primary Outcomes

Area Under the Receiver Operating Characteristic Curve (AUC-ROC) for Detecting Raised Intracranial Pressure

The diagnostic performance of bedside transorbital optic nerve sheath diameter (ONSD) measurement in differentiating between patients with and without raised intracranial pressure will be evaluated using Receiver Operating Characteristic (ROC) curve analysis against the non-contrast brain CT reference standard. The Area Under the Curve (AUC) ranges from 0.5 (no discrimination) to 1.0 (perfect discrimination).

Time frame: baseline