IRE After Chemotherapy for Locally Advanced Pancreatic Cancer

Inclusion Criteria: * Age 18-75 years, any sex. Primary tumor biopsy confirms pancreatic adenocarcinoma. Non-progressive disease (PR or SD) after three cycles of chemotherapy induction. Locally advanced pancreatic cancer with \>180-degree involvement of major vessels (celiac axis, superior mesenteric artery, superior mesenteric vein, or portal vein), confirmed unresectable by MDT review. No prior palliative chemotherapy (except neoadjuvant/adjuvant chemotherapy discontinued \>6 months); no other systemic antitumor therapy. At least one measurable lesion per RECIST 1.1. Adequate organ and marrow function: hemoglobin ≥9.0 g/dL; neutrophils ≥1.5×10⁹/L; platelets ≥100×10⁹/L; TBIL ≤3×ULN; AST and ALT ≤5.0×ULN; serum creatinine ≤1.5×ULN or CrCl \>60 mL/min. ECOG Performance Status 0-1. Expected survival ≥3 months. Patients of childbearing potential and partners agree to use contraception. Voluntary written informed consent. Exclusion Criteria: * Refusal to receive systemic chemotherapy or possible surgery. Metastasis to other sites (liver, peritoneum, lung, bone, brain). History of other malignancies (except cured basal cell carcinoma or cervical carcinoma in situ). Severe uncontrolled comorbidities (NYHA III/IV heart failure, unstable angina, uncontrolled arrhythmia/hypertension, active infection, uncontrolled diabetes, uncontrolled effusions/ascites requiring drainage, severe portal hypertension/cavernoma, gastric outlet obstruction, respiratory insufficiency requiring oxygen). Major surgery within 30 days before screening. EGFR monoclonal antibody within 30 days before screening. Allergy to any drug or component used in this protocol. Known HIV infection or chronic hepatitis B/C. Unresolved toxicity ≥CTCAE grade 2 from prior treatment (except anemia, alopecia, skin pigmentation, chemotherapy-induced neurotoxicity). Any other reason judged by the investigator to make participation inappropriate.